2010

Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity
Biburger M, Theiner G, Schädle M, Schuler G, Tiegs G.
J Leukoc Biol. 2010 Feb;87(2):193-202. Epub 2009 Oct 1.

Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties
Biller L, Davis PH, Tillack M, Matthiesen J, Lotter H, Stanley SL Jr, Tannich E, Bruchhaus I.
BMC Genomics. 2010 Jan 26;11:63.

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes
Kotzka J, Knebel B, Avci H, Jacob S, Nitzgen U, Jockenhovel F, Heeren J, Haas J, Muller-Wieland D
Atherosclerosis. 2010 Nov;213(1):156-65. Epub 2010 Aug 19.

CD4 T cells in hepatic immune tolerance
Carambia A, Herkel J.
J Autoimmun. 2010 Feb;34(1):23-8. Epub 2009 Aug 31. Review.

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J Exp Med. 2010 Aug 2;207(8):1617-24. Epub 2010 Jul 5.

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J
Biochim Biophys Acta. 2010 Feb;1803(2):234-45. Epub 2009 Dec 21.

Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation.
Cramer JP, Lohse AW, Burchard GD, Fischer L, Nashan B, Zimmermann M, Marx A, Kluge S.
Transpl Int. 2010 Feb;23(2):231-3. Epub 2009 Jul 20.

PPFIA1 and CCND1 are frequently coamplified in breast cancer
Dancau AM, Wuth L, Waschow M, Holst F, Krohn A, Choschzick M, Terracciano L, Politis S, Kurtz S, Lebeau A, Friedrichs K, Wencke K, Monni O, Simon R.
Genes Chromosomes Cancer 2010 Jan;49(1):1-8.

Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration
Drucker C, Gewiese J, Malchow S, Scheller J, Rose-John S.
J Autoimmun. 2010 Feb;34(1):29-37. Epub 2009 Aug 29.

Orthotopic Liver Transplantation: Is There a Risk for Listeria monocytogenes Infection?
Ehehalt U, Schmiedel S, Lohse AW.
Case Report Med. 2010;2010:901894. Epub 2010 Mar 11.

Tolerance induction in response to liver inflammation
Erhardt A, Tiegs G.
Dig Dis. 2010;28(1):86-92. Epub 2010 May 7. Review.

How chronic viral infections impact on antigen-specific T-cell responses
Frebel H, Richter K, Oxenius A.
Eur J Immunol. 2010 Mar;40(3):654-63. Review.

Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis
Gehling UM, Willems M, Schlagner K, Benndorf RA, Dandri M, Petersen J, Sterneck M, Pollok JM, Hossfeld DK, Rogiers X.
World J Gastroenterol. 2010 Jan 14;16(2):217-24.

Role of IL-6 trans-signaling in CCl 4 induced liver damage
Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S.
Biochim Biophys Acta. 2010 Nov;1802(11):1054-61. Epub 2010 Aug 3.

HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses
Haas A, Rehr M, Graw F, Rusert P, Bossart W, Kuster H, Trkola A, Günthard HF, Oxenius A.
EMBO Mol Med. 2010 Jun;2(6):231-44.

Identification and characterization of a liver stage-specific promoter region of the malaria parasite Plasmodium
Helm S, Lehmann C, Nagel A, Stanway RR, Horstmann S, Llinas M, Heussler V
PLoS One. 2010 Oct 27;5(10):e13653.

Host cell death induced by the egress of intracellular Plasmodium parasites
Heussler V, Rennenberg A, Stanway R.
Apoptosis. 2010 Mar;15(3):376-85. Review.

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH; IBSEN Study Group, Stokkers PC, Vermeire S, Mathew CG, Lie BA, Beuers U, Manns MP, Schreiber S, Schrumpf E, Häussinger D, Franke A, Karlsen TH.
PLoS One. 2010 Aug 25;5(8):e12403..

tRNA gene sequences are required for transcriptional silencing in Entamoeba histolytica
Irmer H, Hennings I, Bruchhaus I, Tannich E.
Eukaryot Cell. 2010 Feb;9(2):306-14. Epub 2009 Dec 18.

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J Immunol. 2010 Feb 15;184(4):2130-9. Epub 2010 Jan 18.

Genome-wide association analysis in primary sclerosing cholangitis
Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P, Stiehl A, Vermeire S, Beuers U, Manns MP, Schrumpf E, Boberg KM, Schreiber S.
Gastroenterology 2010 Mar;138(3):1102-11.

Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
Kasprowicz V, Kang YH, Lucas M, Schulze zur Wiesch J, Kuntzen T, Fleming V, Nolan BE, Longworth S, Berical A, Bengsch B, Thimme R, Lewis-Ximenez L, Allen TM, Kim AY, Klenerman P, Lauer GM.
J Virol. 2010 Feb;84(3):1656-63.

Spontaneous control of HCV is associated with the expression of HLA-B*57 and preservation of targeted epitopes
Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze Zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GM.
Gastroenterology. 2010 Sep 24. PMID: 20875418.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A
Cell Metab. 2010 Sep 8;12(3):213-23.

Activation of IL-6-induced gp130/STAT3 pathway in mesenchymal stem cells via the trans-signaling mechanism enhances hepatic differentiation, proliferation and liver regeneration
Lam SP, Luk JM, Man K, Cheung CK, Rose-John S, Lo CM.
Liver Transplant 2010; 16: 1195-1206.

The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response
Lehmann E, El-Tantawy WH, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, Tiegs G, Sass G.
Hepatology 2010 Feb;51(2):398-404.

Prospective follow-up of patients with acute hepatitis C virus infection in Brazil
Lewis-Ximenez LL, Lauer GM, Schulze Zur Wiesch J, de Sousa PS, Ginuino CF, Paranhos-Baccalá G, Ulmer H, Pfeiffer KP, Goebel G, Pereira JL, Mendes de Oliveira J, Yoshida CF, Lampe E, Velloso CE, Alves Pinto M, Coelho HS, Almeida AJ, Fernandes CA, Kim AY, Strasak AM.
Clin Infect Dis. 2010 May 1;50(9):1222-30.

Immune-mediated liver injury
Lohse AW, Weiler-Normann C, Tiegs G.
J Hepatol. 2010 Jan;52(1):136-44. Epub 2009 Oct 24.

In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice
Lutgehetmann M, Volz T, Köpke A, Broja T, Tigges E, Lohse AW, Fuchs E, Murray JM, Petersen J, Dandri M.
Hepatology 2010; 52(1):16-24.

Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis
Manns MP, Woynarowski M, Kreisel W, Lurie Y, Rust C, Zuckerman E, Bahr MJ, Günther R, Hultcrantz RW, Spengler U, Lohse AW, Szalay F, Färkkilä M, Pröls M, Strassburg CP; European AIH-BUC-Study Group.
Gastroenterology. 2010 Oct;139(4):1198-206. Epub 2010 Jun 22.

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T
J Immunol. 2010 Feb 1;184(3):1543-51. Epub 2009 Dec 30.

Case report of aseptic meningitis in a patient with Crohn’s disease under infliximab therapy
Manthey C, Lohse AW, Pace A.
Inflamm Bowel Dis. 2010 May 10. [Epub ahead of print].

Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis
Palioura S, Herkel J, Simonović M, Lohse AW, Söll D.
Biol Chem. 2010 Jul;391(7):771-6.

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite
Putrianti ED, Schmidt-Christensen A, Arnold I, Heussler VT, Matuschewski K, Silvie O.
Cell Microbiol. 2010 Jun;12(6):725-39. Epub 2009 Dec 21.

Imaging liver-stage malaria parasites
Rankin KE, Graewe S, Heussler VT, Stanway RR.
Cell Microbiol. 2010 May 1;12(5):569-79. Epub 2010 Feb 19. Review

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes
Rennenberg A, Lehmann C, Heitmann A, Witt T, Hansen G, Nagarajan K, Deschermeier C, Turk V, Hilgenfeld R, Heussler VT.
PLoS Pathog. 2010 Mar 26;6(3):e1000825.

On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection.
Richter K, Agnellini P, Oxenius A.
Int Immunol. 2010 Jan;22(1):13-23. Epub 2009 Oct 30.

A role for IL-18 in protective immunity against Mycobacterium tuberculosis
Schneider BE, Korbel D, Hagens K, Koch M, Raupach B, Enders J, Kaufmann SH, Mittrücker HW, Schaible UE.
Eur J Immunol. 2010 Feb;40(2):396-405.

Primary liver transplantation for autoimmune hepatitis: a comparative analysis of the European Liver Transplant Registry
Schramm C, Bubenheim M, Adam R, Karam V, Buckels J, O’Grady JG, Jamieson N, Pollard S, Neuhaus P, Manns MM, Porte R, Castaing D, Paul A, Traynor O, Garden J, Friman S, Ericzon BG, Fischer L, Vitko S, Krawczyk M, Metselaar HJ, Foss A, Kilic M, Rolles K, Burra P, Rogiers X, Lohse AW; European Liver Intestine Transplant Association.
Liver Transpl 2010 Apr;16(4):461-9.

Treatment response in patients with autoimmune hepatitis
Schramm C, Weiler-Normann C, Wiegard C, Hellweg S, Müller S, AW Lohse.
Hepatology. 2010 Dec;52(6):2247-8. doi: 10.1002/hep.23840. Epub 2010 Jul 29.

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease
Schulze Zur Wiesch J, Thomssen A, Hartjen P, Toth I, Lehmann C, Meyer-Olson D, Colberg K, Frerk S, Babikir D, Schmiedel S, Degen O, Mauss S, Rockstroh J, Staszewski S, Khaykin P, Strasak A, Lohse AW, Fätkenheuer G, Hauber J, van Lunzen J.
J Virol. 2010 Nov 3. [Epub ahead of print].

TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium
Seibert SA, Mex P, Köhler A, Kaufmann SH, Mittrücker HW.
Immunol Lett. 2010 Jan 4;127(2):126-34. Epub 2009 Nov 4.

A role for IL-27p28 as an antagonist of gp130-mediated signaling
Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O’Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA.
Nat Immunol. 2010 Dec;11(12):1119-26. Epub 2010 Nov 7.

Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J.
Mol Biol Cell. 2010 Aug 1;21(15):2797-807. Epub 2010 Jun 16.

Concurrent autoimmune diseases in patients with autoimmune hepatitis
Teufel A, Weinmann A, Kahaly GJ, Centner C, Piendl A, Wörns M, Lohse AW, Galle PR, Kanzler S.
J Clin Gastroenterol. 2010 Mar;44(3):208-13.

Immune tolerance: what is unique about the liver
Tiegs G, Lohse AW.
J Autoimmun. 2010 Feb;34(1):1-6. Epub 2009 Aug 29. Review.

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis
Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker HW, Tiegs G, Stahl RA, Panzer U.
J Am Soc Nephrol 2010 Jun;21(6):974-85.

The replication cycle of hepatitis B virus
Urban S, Schulze A, Dandri M, Petersen J.
J Hepatol. 2010 Feb;52(2):282-4. Epub 2009 Nov 24. No abstract available.

Programmed cell death in unicellular parasites: a prerequisite for sustained infection?
van Zandbergen G, Lüder CG, Heussler V, Duszenko M.
Trends Parasitol. 2010 Oct;26(10):477-83. Epub 2010 Jun 28.

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
J Biol Chem. 2010 Jan 15;285(3):1781-9. Epub 2009 Nov 13.

Telomere und Telomerase in Zellalterung und Karzinogenese
Wege H, Brümmendorf TH
BioSpektrum 2010; 3: 271-3.

Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP1
Weiss R, Gabler M, Jacobs T, Gilberger TW, Thalhamer J, Scheiblhofer S.
Vaccine. 2010 Jun 17;28(28):4515-22. Epub 2010 May 15.

Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses
Wiesel M, Joller N, Ehlert AK, Crouse J, Spörri R, Bachmann MF, Oxenius A.
J Immunol. 2010 Nov 1;185(9):5188-97. Epub 2010 Sep 29.

Type I IFN substitutes for T cell help during viral infections
Wiesel M, Kratky W, Oxenius A
J Immunol. 2011 Jan 15;186(2):754-63. Epub 2010 Dec 15.