2015

Abramowski P, Kraus O, Rohn S, Riecken K, Fehse B, Schlüter H

Combined Application of RGB Marking and Mass Spectrometric Imaging Facilitates Detection of Tumor Heterogeneity
Cancer Genomics Proteomics. 2015 07-08;12(4):179-187.

Ahmed M, Kumar G, Navarro G, Wang Y, Gourevitch S, Moussa MH, Rozenblum N, Levchenko T, Galun E, Torchilin VP, Goldberg SN

Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy
PLoS One. 2015 Jul 8;10(7):e0128910. doi: 10.1371/journal.pone.0128910. eCollection 2015.

Carambia A, Freund B, Schwinge D, Bruns OT, Salmen SC, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wraith DC, Korn T, Nielsen P, Weller H, Schramm C, Lüth S, Lohse AW, Heeren J, Herkel J

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

J Hepatol. 2015 Jun;62(6):1349-56. doi: 10.1016/j.jhep.2015.01.006. Epub 2015 Jan 21.

Dammermann W, Bentzien F, Stiel EM, Kühne C, Ullrich S, Schulze Zur Wiesch J, Lüth S

Development of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients
J Transl Med. 2015 May 13;13:157. doi: 10.1186/s12967-015-0513-1.

Dandri M, Bockmann JH

The challenge of protecting without overprotecting: the two sides of myeloid-derived suppressor cells in HBV infection
Hepatology. 2015 Dec 10. doi: 10.1002/hep.28385. [Epub ahead of print]

Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H

Magnetic Resonance Imaging of Pathogenic Protozoan Parasite Entamoeba histolytica Labeled With Superparamagnetic Iron Oxide Nanoparticles
Invest Radiol. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175.

Galun E.

Liver inflammation and cancer: The role of tissue microenvironment in generating the tumor-promoting niche (TPN) in the development of hepatocellular carcinoma
Hepatology. 2015 Nov 13. doi: 10.1002/hep.28344. [Epub ahead of print]

Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J

Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism
Cancer Res. 2015 Jul 1;75(13):2663-73. doi:10.1158/0008-5472.CAN-14-3635. Epub 2015 May 14.

Giersch K, Allweiss L, Volz T, Helbig M, Bierwolf J, Lohse AW, Pollok JM, Petersen J, Dandri M, Lütgehetmann M

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
J Hepatol. 2015 Aug;63(2):346-53. doi: 10.1016/j.jhep.2015.03.011. Epub 2015 Mar 17.

Giersch K, Dandri M

Hepatitis B and Delta Virus: Advances on Studies about Interactions between the Two Viruses and the Infected Hepatocyte
J Clin Transl Hepatol. 2015 Sep 28;3(3):220-9. doi: 10.14218/JCTH.2015.00018. Epub 2015 Sep 15. Review.

Gomez-Nicola D, Riecken K, Perry VH, Fehse B

Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level
Hum Gene Ther. 2015 Jun;26(6):332-3. doi:10.1089/hum.2015.010. Epub 2015 Apr 20.

Hartl J, Ehlken H, Weiler-Normann C, Sebode M, Kreuels B, Pannicke N, Zenouzi R, Glaubke C, Lohse AW, Schramm C

Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis
J Hepatol. 2015 Mar;62(3):642-6. doi: 10.1016/j.jhep.2014.10.018. Epub 2014 Oct 18

Heim D, Cornils K, Schulze K, Fehse B, Lohse AW, Brümmendorf AW, Wege H

Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
Oncogene. 2015 Jan 15;34(3):364-72. doi: 10.1038/onc.2013.551. Epub 2014 Jan 13

Herkel J.

Regulatory T Cells in Hepatic Immune Tolerance and Autoimmune Liver Diseases
Dig Dis. 2015;33 Suppl 2:70-4. doi: 10.1159/000440750. Epub 2015 Dec 7.

Höchst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis
PLoS One. 2015 Mar 4;10(3):e0119662. doi: 10.1371/journal.pone.0119662. eCollection 2015

Jiménez-Alcázar M, Napirei M, Panda R, Köhler EC, Kremer Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
J Thromb Haemost. 2015 May;13(5):732-42. doi:10.1111/jth.12796. Epub 2015 Apr 13.

Karimova M, Beschorner N, Dammermann W, Chemnitz J, Indenbirken D, Bockmann JH, Grundhoff A, Lüth S, Buchholz F, Wiesch JS, Hauber J

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X
Sci Rep. 2015 Sep 3;5:13734. doi: 10.1038/srep13734. PubMed PMID: 26334116.

Kaul MG, Weber O, Heinen U, Reitmeier A, Mummert T, Jung C, Raabe N, Knopp T, Ittrich H, Adam G

Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice
Rofo. 2015 May;187(5):347-52. doi:10.1055/s-0034-1399344. Epub 2015 Apr 21.

Kenne E, Nickel KF, Long AT, Fuchs TA, Stavrou EX, Stahl FR, Renné T

Factor XII: a novel target for safe prevention of thrombosis and inflammation
J Intern Med. 2015 Sep 16. doi: 10.1111/joim.12430. [Epub ahead of print] Review.

Lapke N, Tartz S, Lee KH, Jacobs T

The application of anti-Toso antibody enhances CD8 T cell responses in experimental malaria vaccination and disease
Vaccine. 2015 Nov 27;33(48):6763-70. doi: 10.1016/j.vaccine.2015.10.065. Epub 2015 Oct 25.

Long AT, Kenne E, Jung R, Fuchs TA, Renné T

Contact system revisited: an interface between inflammation, coagulation, and innate immunity
J Thromb Haemost. 2015 Dec 26. doi: 10.1111/jth.13235. [Epub ahead of print] Review.

Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FH, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Nat Biotechnol. 2015 May;33(5):549-54. doi: 10.1038/nbt.3179. Epub 2015 Mar 23.

Raabe N, Forberich E, Freund B, Bruns OT, Heine M, Kaul MG, Tromsdorf U, Herich L, Nielsen P, Reimer R, Hohenberg H, Weller H, Schumacher U, Adam G, Ittrich H

Determination of liver-specific r2 * of a highly monodisperse USPIO by (59) Fe iron core-labeling in mice at 3 T MRI
Contrast Media Mol Imaging. 2015 Mar-Apr;10(2):153-62. doi: 10.1002/cmmi.1612. Epub 2014 Jul 30.

Rose-John S, Scheller J, Schaper F

“Family reunion”—A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines
Cytokine Growth Factor Rev. 2015 Oct;26(5):471-4. doi: 10.1016/j.cytogfr.2015.07.011. Epub 2015 Jul 6.

Rozenblum N, Zeira E, Bulvik B, Gourevitch S, Yotvat H, Galun E, Goldberg SN

Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, Including Liver Regeneration
Radiology. 2015 Aug;276(2):416-25. doi: 10.1148/radiol.15141918. Epub 2015 Mar 30.

Rozenblum N, Zeira E, Scaiewicz V, Bulvik B, Gourevitch S, Yotvat H, Galun E, Goldberg SN

Oncogenesis: An “Off-Target” Effect of Radiofrequency Ablation
Radiology. 2015 Aug;276(2):426-32. doi: 10.1148/radiol.2015141695.

Schaper F, Rose-John S

Interleukin-6: Biology, signaling and strategies of blockade
Cytokine Growth Factor Rev. 2015 Oct;26(5):475-87. doi:10.1016/j.cytogfr.2015.07.004. Epub 2015 Jul 4. Review.

Scheja L, Kluwe J

Arginine and NASH—do macrophages deliver the first hit?
J Hepatol. 2015 Feb;62(2):260-1. doi: 10.1016/j.jhep.2014.11.001. Epub 2014 Nov 8.

Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Koch-Nolte F, Mittrücker HW

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation
PLoS One. 2015 May 4;10(5):e0126007. doi: 10.1371/journal.pone.0126007. eCollection 2015.

Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse AW, Herkel J, Schramm C

Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis
J Immunol. 2015 Mar 15;194(6):2522-30. doi: 10.4049/jimmunol.1400076. Epub 2015 Feb 11.

Sebode M, Schramm C

Natural killer T cells: Novel players in biliary disease?
Hepatology. 2015 Oct;62(4):999-1000. doi: 10.1002/hep.27862. Epub 2015 Jun 3.

Sebode M, Peiseler M, Weiler-Normann C, Schramm C, Lohse AW, Herkel J

Phenotypic alterations of regulatory T cells in autoimmune hepatitis: causal or associated with treatment and remission?
Hepatology. 2015 Feb;61(2):736-7. doi: 10.1002/hep.27301. Epub 2015 Jan 5.

Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi RF, Vertino PM, Cedar H, Galun E, Goldenberg D

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis
Oncotarget. 2015 May 10;6(13):11047-60.

Wagner T, Bartelt A, Schlein C, Heeren J

Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
PLoS One. 2015 Dec 22;10(12):e0145102. doi:10.1371/journal.pone.0145102. eCollection 2015.

Wehmeyer MH, Jordan S, Lüth S, Hartl J, Stoehr A, Eißing C, Lohse AW, Petersen J, Buggisch P, Schulze Zur Wiesch J

Efficacy and safety of sofosbuvir-based triple therapy in hepatitis C genotype 4 infection
Dig Liver Dis. 2015 May 24. pii: S1590-8658(15)00347-3. doi: 10.1016/j.dld.2015.05.018. [Epub ahead of print]

Worm M, Köhler EC, Panda R, Long A, Butler LM, Stavrou EX, Nickel KF, Fuchs TA, Renné T

The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities
Ann Transl Med. 2015 Oct;3(17):247. doi:10.3978/j.issn.2305-5839.2015.09.07. Review.

Zahavi T, Lanton T, Divon MS, Salmon A, Peretz T, Galun E, Axelrod JH, Sonnenblick A

Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model
Oncotarget. 2015 Dec 17. doi: 10.18632/oncotarget.6638. [Epub ahead of print]