2017

Allweiss L, Volz T, Giersch K, Kah J, Raffa G, Petersen J, Lohse AW, Beninati C, Pollicino T, Urban S, Lütgehetmann M, Dandri M

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo
Gut. 2017 Apr 20. pii: gutjnl-2016-312162. doi: 10.1136/gutjnl-2016-312162. [Epub ahead of print]

Allweiss L, Lütgehetmann M, Dandri M

Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
Methods Mol Biol. 2017;1540:135-142. PubMed PMID: 27975313.

Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Nat Commun. 2017 Apr 19;8:15010. doi: 10.1038/ncomms15010.

Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

Hepatology. 2017 Jan;65(1):89-103. doi: 10.1002/hep.28874. Epub 2016 Nov 22.

Beudeker BJB, van Oord GW, Arends JE, Schulze Zur Wiesch J, van der Heide MS, de Knegt RJ, Verbon A, Boonstra A, Claassen MAA.

MAIT-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis
Liver Int. 2017 Aug 9. doi: 10.1111/liv.13544. [Epub ahead of print]

Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo
J Immunol. 2017 Feb 1;198(3):1130-1141.

Chai C, Rivkin M, Berkovits L, Simerzin A, Zorde-Khvalevsky E, Rosenberg N, Klein S, Yaish D, Durst R, Shpitzen S, Udi S, Tam J, Heeren J, Worthmann A, Schramm C, Kluwe J, Ravid R, Hornstein E, Giladi H, Galun E.

Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues
Gastroenterology. 2017 Aug 9. pii: S0016-5085(17)36024-9. doi:10.1053/j.gastro.2017.08.013. [Epub ahead of print]

Deterding K, Spinner CD, Schott E, Welzel TM, Gerken G, Klinker H, Spengler U, Wiegand J, Schulze Zur Wiesch J, Pathil A, Cornberg M, Umgelter A, Zöllner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns MP, Wedemeyer H; HepNet Acute HCV IV Study Group

Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV): an open-label, single-arm, phase 2 study.
Lancet Infect Dis. 2017 Feb;17(2):215-222. doi: 10.1016/S1473-3099(16)30408-X. Epub 2016 Oct 28

Dieckhoff J, Kaul MG, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H

In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach
Phys Med Biol. 2017 May 7;62(9):3470-3482. doi: 10.1088/1361-6560/aa562d. Epub 2016 Dec 30

Dieckhoff J, Kaul MG, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H

Magnetic Particle Imaging of liver tumors in small animal models
International Journal On Magnetic Particle Imaging, 2017;3

Giersch K, Allweiss L, Volz T, Dandri M, Lütgehetmann M

Serum HBV pgRNA as a clinical marker for cccDNA activity
J Hepatol. 2017 Feb;66(2):460-462. doi:10.1016/j.jhep.2016.09.028.

Giersch K, Homs M, Volz T, Helbig M, Allweiss L, Lohse A W, Petersen J, Buti M, Pollicino T, Sureau C, Dandri M, Lütgehetmann M

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice
Sci Rep. 2017; 7: 3757. Published online 2017 Jun 16. doi: 10.1038/s41598-017-03946-9

Griesbeck M, Valantin MA, Lacombe K, Samri-Hassimi A, Bottero J, Blanc C, Sbihi Z, Zoorob R, Katlama C, Guiguet M, Altfeld M, Autran B; HepACT-VIH study group

HCV drives increased type I IFN-associated impairments associated to fibrosis severity in ART-treated HIV-1-HCV coinfected individuals
AIDS. 2017 Mar 21. doi: 10.1097/QAD.0000000000001455. [Epub ahead of print]

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells
Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28

Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lütgehetmann M, Bertoletti A, Dandri M

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection
J Clin Invest. 2017 Jul 24. pii: 93024. doi: 10.1172/JCI93024. [Epub ahead of print]

Krawczyk M, Rau M, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Lammert F, Geier A (NAFLD Clinical Study Group)

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study
J Lipid Res. 2017 Jan;58(1):247-255. doi: 10.1194/jlr.P067454.

Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose John S, Galun E, Axelrod JH

Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis
Hepatology. 2017 May;65(5):1600-1611. doi: 10.1002/hep.29004. Epub 2017 Mar 23

Lohse AW, Herkel J, Weiler-Normann C

Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?
Dig Dis. 2017;35(4):367-370. doi: 10.1159/000456588. Epub 2017 May 3.

Lunemann S, Martrus G, Goebels H, Kautz T, Langeneckert A, Salzberger W, Koch M, J Bunders M, Nashan B, van Gisbergen KPJM, Altfeld M

Hobit expression by a subset of human liver-resident CD56 Natural Killer cells
Sci Rep. 2017 Jul 27;7(1):6676. doi: 10.1038/s41598-017-06011 7.

Martrus G, Kautz T, Lunemann S, Richert L, Glau L, Salzberger W, Goebels H, Langeneckert A, Hess L, Poch T, Schramm C, Oldhafer KJ, Koch M, Tolosa E, Nashan B, Altfeld M.

Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells
PLoS One. 2017 Aug 9;12(8):e0182532. doi:10.1371/journal.pone.0182532. eCollection 2017

Mohme M, Maire CL, Riecken K, Zapf S, Aranyossy T, Westphal M, Lamszus K, Fehse B

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity
Mol Ther. 2017 Mar 1;25(3):621-633. doi: 10.1016/j.ymthe.2016.12.014. Epub 2017 Jan 18

Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst AK, Tiegs G

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
J Immunol. 2017 Jan 1;198(1):128-137.

Nickel KF, Long AT, Fuchs TA, Butler LM, Renné T

Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases
Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. doi: 10.1161/ATVBAHA.116.308595.

Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Conrad K, Csernok E, Fuchs TA

Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
Front Immunol. 2017 Apr 13;8:439. doi: 10.3389/fimmu.2017.00439. eCollection 2017

Schwinge D*, von Haxthausen F*, Quaas A, Carambia A, Otto B, Glaser F, Höh B, Thiele N, Schoknecht T, Huber S, Steffens N, Lohse AW, Herkel J, Schramm C

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related with IL-12 signaling
J Hepatol. 2017 Apr;66(4):798-805. doi: 10.1016/j.jhep.2016.12.001. Epub 2016 Dec 10.
*equally contributing authors

Thiele ND, Wirth JW, Steins D, Koop AC, Ittrich H, Lohse AW, Kluwe J

TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
Sci Rep. 2017 Apr 6;7(1):714. doi: 10.1038/s41598-017-00671-1

Verhoef JJ, Barendrecht AD, Nickel KF, Dijkxhoorn K, Kenne E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, de Maat S,Renné T, Maas C

Polyphosphate nanoparticles on the platelet surface trigger contact system activation
Blood. 2017 Jan 3. pii: blood-2016-08-734988. doi: 10.1182/blood-2016-08-734988. Epub 2017 Jan 3

Wehmeyer MH, Ingiliz P, Christensen S, Hueppe D, Lutz T, Simon KG, Schewe K, Boesecke C, Baumgarten A, Busch H, Rockstroh J, Schmutz G, Kimhofer T, Berger F, Mauss S, Wiesch JSZ

Real-world effectiveness of sofosbuvir-based treatment regimens for chronic hepatitis C genotype 3 infection: results from the multicenter German hepatitis C cohort (GECCO-03)
J Med Virol. 2017 Jul 15. doi: 10.1002/jmv.24903. [Epub ahead of print]

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2
J Hepatol. 2017 May;66(5):978-986. doi: 10.1016/j.jhep.2016.12.015. Epub 2016 Dec 23

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L,Franke A, Shaul PW, Heeren J.

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Nat Med. 2017 Jun 12. doi: 10.1038/nm.4357. [Epub ahead of print] PubMed PMID: 28604703.