Current liver research: Curing chronic hepatitis C virus infection by blocking its liver cell entry
23 March 2015
An international collaborative study led by the University of Strasbourg has demonstrated a novel way how chronic hepatitis C infection can be cured. Instead of attacking the virus itself, the scientists target a liver protein which serves as a door for the virus entry into the cell. A humanized mouse model developed in the lab of Prof. Maura Dandri (also head of SFB 841 project A5) was used to succesfully test the new therapeutic approach in human liver cells.
Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FH, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Nat Biotechnol. 2015 Mar 23. doi: 10.1038/nbt.3179. [Epub ahead of print]