Decoding primary sclerosing cholangitis

5 January 2016

Primary sclerosing cholangitis, or PSC, is a rare, chronic, scarring disease of the bile ducts inside and outside the liver. It mainly affects young adults and leads to cirrhosis of the liver within 10 to 20 years. Although the disease is frequently fatal, its progress is largely unresearched. This situation hopefully changes in near future: Scientists and clinicians from Hamburg have set up the Clinical Research Unit 306 “Primary sclerosing cholangitis” to comprehensively understand and decipher this complex disease. The German Research Foundation supports the research initiative with more than four million euros in the next three years.

KFO 306

Please download the press information here (in German).

The Clinical Research Unit 306 focuses on a single disease and therefore complements the research activities within the Collaborative Research Center 841, whose focus is to understand the complex interplay between liver injury, inflammation and repair. The spokesman, Prof. Dr. Ansgar W. Lohse, and the designated head of the Clinical Research Unit, Prof. Dr. Christoph Schramm, both have a lot of experience with the pathogenesis, diagnosis and treatment of autoimmune liver diseases.

Prof. Schramm directs the CRC 841 project B3 “Regulatory T cells and TH17 cells in the pathogenesis and treatment of cholangitis.” Project description, recent publications and contact details can be found here.

The Yael Foundation supports the outpatient clinic for autoimmune liver diseases within the Martin Zeitz Center for Rare Diseases at the University Medical Center Hamburg-Eppendorf. The flyer of the foundation can be downloaded here (in German).