A7 - HCV infection: Mechanisms of NK-cell-mediated control
Prof. Dr. med. Marcus Altfeld
Head, Research Unit Viral Immunology
Heinrich Pette Institute (HPI)
Leibniz Institute for Experimental Virology
E mail: firstname.lastname@example.org
Natural Killer cells (NK cells) play an important role in the initial immune response against viral infections, including HCV infection. The precise mechanisms by which NK cells recognize HCV-infected cells and reduce viral replication are not understood.
A better understanding of the mechanisms by which NK cells can lead to a better outcome of HCV infection will contribute not only to the development of new immunotherapeutic interventions in HCV infection, but also other human chronic viral infections.
A7 in 60 SecondsVideoarchivonline seit 23.02.2014
Previous studies have demonstrated that specific genotypes of NK cell receptors (Killer cell-Immunoglobulin-like receptors, or KIRs) in conjunction with their HLA class I ligands are associated with a better outcome of HCV infection. We furthermore showed that NK cells expressing these KIRs are preferentially expanded in individuals with cleared HCV infection.
We now plan to determine how these KIR+ NK cells recognize HCV-infected cells, and how HCV can evade this NK cell-mediated immune selection pressure.
Martrus G, Kautz T, Lunemann S, Richert L, Glau L, Salzberger W, Goebels H, Langeneckert A, Hess L, Poch T, Schramm C, Oldhafer KJ, Koch M, Tolosa E, Nashan B, Altfeld M.
Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells
PLoS One. 2017 Aug 9;12(8):e0182532. doi:10.1371/journal.pone.0182532. eCollection 2017
Lunemann S, Martrus G, Goebels H, Kautz T, Langeneckert A, Salzberger W, Koch M, J Bunders M, Nashan B, van Gisbergen KPJM, Altfeld M
Hobit expression by a subset of human liver-resident CD56 Natural Killer cells
Sci Rep. 2017 Jul 27;7(1):6676. doi: 10.1038/s41598-017-06011 7.
Lunemann S, Martrus G, Hölzemer A, Chapel A, Ziegler M, Körner C, Beltran WG, Carrington M, Wedemeyer H, Altfeld M
Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C(∗)03:04 and modulate NK cell function
J Hepatol. 2016 Apr 4. pii: S0168-8278(16)30097-6. doi:10.1016/j.jhep.2016.03.016. [Epub ahead of print]
Video abstract english "Sequence variations in HCV core-derived epitopes...Videoarchivonline seit 07.06.2016
Jost S, Altfeld M
Control of human viral infections by natural killer cells
Annu Rev Immunol. 2013;31:163-94. doi: 10.1146/annurev-immunol-032712-100001. Epub 2013 Jan 3.