A8 Hepatitis D virus: pathogenesis and interaction with innate immune system

A5 und A8_April 2014

Principal investigators:

Lütgehetmann, Marc; Dr. med.
Institut für Mikrobiologie, Virologie und Hygiene
Universitätsklinik Hamburg-Eppendorf
Martinistr.52
20246 Hamburg
Tel.: +49-40-7410-52949
mluetgeh@uke.de

Dandri, Maura; Prof. Dr. rer. nat.,
Medizinische Klinik und Poliklinik
Martinistr.52
20246 Hamburg
Tel.: +49-40-7410-52949
m.dandri@uke.de

Project description

Approximately 20 Million individuals are chronically infected with the Hepatitis Delta Virus (HDV) worldwide. HDV infection is considered the most severe form of viral hepatitis. Due to the lack of robust and reliable HDV-infection models, knowledge about the molecular mechanisms of HDV-mediated pathogenesis is still scant.

A8 in 60 SecondsVideoarchiv

online seit 05.09.2014

We recently demonstrated the establishment of a new model of HDV infection by employing human liver chimeric uPA/SCID mice. Using this new in vivo infection system we will study interactions between HDV and the innate immune responses of the infected human hepatocytes, as well as the antiviral or protective effect of new substances, such as pegylated interferon lambda, interleukin-22 and viral entry inhibitors. Furthermore, to study the role of adaptive immune components in HDV infection, we plan to develop innovative immune competent mouse systems of HDV infection.

Figure 1: Generation of humanized uPA/SCID mice for HBV/HDV studies. After transplantation the mouse liver is stably reconstituted with human hepatocytes (blue) which can be infected with HDV (red) and HBV (green).

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Videoabstract english "Persistent Hepatitis D Virus mono-infection ..."Videoarchiv

online seit 17.01.2014