B3 - Role of regulatory T cells and TH17 cells for the pathogenesis and treatment of cholangitis

B3_April 2014

Principal Investigator:
Prof. Dr. med. Christoph Schramm
I. Department of Internal Medicine
University Medical Center Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg
Germany
Phone: +49-40-7410-52545
Fax: +49-40-7410-40001
E-Mail: cschramm@uke.de

Project description

Primary (PSC) and secondary sclerosing cholangitis often progresses to liver cirrhosis and end stage liver disease. This is due to inflammation and fibrosis at the mucosal barrier of bile ducts.

At this interface, immune reactions must be well balanced in order to limit inflammation but allow proper pathogen defence. Regulatory T cells (Treg) and IL-17 producing TH17 cells are key players in the regulation of mucosal immunity because they are involved both in the development of autoimmunity and in pathogen defence.

B3 in 60 SecondsVideoarchiv

online seit 14.12.2012

In project B3 we aim to define the pathogenetic role of these cells for the development of experimental cholangitis and to investigate whether the modulation of Treg and TH17 cells could be used for the future treatment of primary and secondary forms of sclerosing cholangitis.

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