C8 - IL-22 and IL-22BP in liver regeneration and carcinogenesis
Prof. Dr. med. Samuel Huber
I. Medizinische Klinik und Poliklinik
Interleukin 22 (IL-22) is a pleiotropic cytokine, which may have protective and pathogenic properties depending on the environment. It particularly plays a role during regeneration, infection, and carcinogenesis. Normally, IL-22 binds to the membrane-bound IL-22 receptor (IL-22r1) thereby exerting its activities. However, there is also a soluble IL-22 receptor, the IL-22 binding protein (IL-22BP), which binds and neutralizes IL-22.
IL-22 seems to play a protective role during liver regeneration. However, uncontrolled IL-22 activity might promote liver cancer.
C8 in 60 SecondsVideoarchivonline seit 17.03.2014
Our previous findings have shown that IL-22BP plays a crucial role in controlling the activity of IL-22 during wound healing and carcinogenesis. Now we aim to identify the cellular source of IL-22 and IL-22BP in the liver. Furthermore, we are interested in the pathways regulating IL-22 and IL-22BP production. Finally, we want to investigate the interaction between IL-22 and IL-22BP and how this controls liver regeneration and carcinogenesis.
Our long-term aim is to identify new therapeutic strategies that, on the one hand, promote liver regeneration and, on the other hand, inhibit liver carcinogenesis.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA.
Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17.