C9 - Role of extracellular DNA in liver regeneration and carcinogenesis

C9_April 2014

Principal Investigator:
Tobias Fuchs, PhD
Institute of Clinical Chemistry and Laboratory Medicine
University Medical Center Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg
Tel.: +49-40-7410-51908
E-mail: t.fuchs@uke.de

Project description

Inflammation plays a crucial role in tissue regeneration and in the development of cancer. Neutrophils are the dominating cell type during acute inflammation. Neutrophils are capable of releasing their DNA from the nucleus into the extracellular environment to form extracellular webs known as Neutrophil Extracellular Traps (NETs).

C9 in 60 SecondsVideoarchiv

online seit 22.03.2014
C9_Spider web and NET
Figures: Spider web with dewdrops (left) and NETs (right) in blue with green platelets

In order to release its DNA, the nucleus of neutrophils undergoes certain morphological changes which are summarized in the process of NETosis. Once liberated into the extracellular environment, DNA forms a fibrous network, which resembles the appearance of a spider web. NETs can interact with other cells and proteins and the goal of this project is to understand their role in liver regeneration and cancer.

Related News:

Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Conrad K, Csernok E, Fuchs TA

Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
Front Immunol. 2017 Apr 13;8:439. doi: 10.3389/fimmu.2017.00439. eCollection 2017

Jiménez-Alcázar M, Napirei M, Panda R, Köhler EC, Kremer Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
J Thromb Haemost. 2015 May;13(5):732-42. doi:10.1111/jth.12796. Epub 2015 Apr 13.