Z1 - MR tomographic imaging of liver diseases – non-invasive strategies for the control of liver regeneration, tumor therapy and cell therapy concepts

Z1_April 2014

Principal Investigators:
PD Dr. med. Harald Ittrich
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie
Universitätsklinikum Hamburg-Eppendorf
Martinistrasse 52
20246 Hamburg
Germany
Tel.: +49-40-7410-53810
Fax: +49-40-7410-57165
E-Mail: ittrich@uke.de

Prof. Dr. med. Gerhard Adam
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie
Universitätsklinikum Hamburg-Eppendorf
Martinistrasse 52
20246 Hamburg
Germany
Tel.: +49-40-7410-54029
Fax: +49-40-7410-53802
E-Mail: g.adam@uke.de

Project Description

Magnetic resonance imaging is a valuable technique well established in clinical practice. It does not only allow for anatomical images but can also yield information about the functional properties of tissue. Using a dedicated magnetic resonance scanner at a high magnetic field strength it is possible to acquire high quality high resolution images from small animals.

Anatomical and functional magnetic resonance imaging of the liver allows for a deep understanding of the processes underlying a disease model. It constitutes a gentle approach that can greatly help to reduce the required number of animals in a range of experiments.

SP1 in 60 SecondsVideoarchiv

online seit 02.12.2012

In the first period of the SFB grand, we established the magnetic resonance imaging as a standardized diagnostic technique in Hamburg. We developed new approaches to image the murine biliary system and could show that it is possible to visualise parasitic amebae in the liver, by labeling them with nanoparticles.

In the future, we will continue to support our partners in the SFB with an optimum of diagnostic imaging. For example, we will implement a new diagnostic technique developed in Hamburg, the magnetic particle imaging, with the very first commercially available MPI scanner worldwide.

Related news:

Dieckhoff J, Kaul MG, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H

In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach
Phys Med Biol. 2017 May 7;62(9):3470-3482. doi: 10.1088/1361-6560/aa562d. Epub 2016 Dec 30

Keller S, Ittrich H, Schramm C, Lohse AW, Amling M, Adam G, Yamamura J

Diffusion-weighted MRI for detection of hepatic osteodystrophy in Primary sclerosing cholangitis: a comparison study with dual-energy X-ray absorptiometry
Jpn J Radiol. 2016 Oct;34(10):677-683.

Jung CS, Heine M, Freund B, Reimer R, Koziolek EJ, Kaul MG, Kording F, Schumacher U, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H

Quantitative Activity Measurements of Brown Adipose Tissue at 7 T Magnetic Resonance Imaging After Application of Triglyceride-Rich Lipoprotein 59Fe-Superparamagnetic Iron Oxide Nanoparticle: Intravenous Versus Intraperitoneal Approach
Invest Radiol. 2016 Mar;51(3):194-202. doi: 10.1097/RLI.0000000000000235.