Z1 MRI and MPI of liver disease - non-invasive control of liver and bile duct inflammation, tumourgenesis, steatosis, fibrosis and pathogenic parasites

Z1_April 2014

Principal Investigators:
PD Dr. med. Harald Ittrich
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie und Nuklearmedizin
Universitätsklinikum Hamburg-Eppendorf
Martinistrasse 52
20246 Hamburg
Germany
Tel.: +49-40-7410-53810
Fax: +49-40-7410-57165
E-Mail: ittrich@uke.de

Prof. Dr. med. Gerhard Adam
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie und Nuklearmedizin
Universitätsklinikum Hamburg-Eppendorf
Martinistrasse 52
20246 Hamburg
Germany
Tel.: +49-40-7410-54029
Fax: +49-40-7410-53802
E-Mail: g.adam@uke.de

Participating staff:
Dr. rer. nat. Julia Wernecke – PostDoc
Michael Kaul, Dipl.-phys.
Johannes Salomon – M.D.
Caroline Jung – M.D.
Tobias Mummert – Tecnical Assistant

Project Description

Magnetic Resonance Imaging (MRI) has been used in clinical practice for 30 years to produce cross-sectional images, which, in addition to anatomical imaging, also enable the capture of functional properties of tissues. With the help of a special high-field magnetic resonance tomograph (MRI) man-made MR imaging can be used even in small animals.

Magnetic Particle Imaging (MPI) is a promising new imaging modality based on the signals of superparamagnetic nanoparticles (SPIO). MPI has a very high temporal resolution (> 40 volume scans / sec) and good sensitivity, and can provide a direct image of the liver SPIO distribution in liver imaging, allowing detection of liver tumors or temperature measurement of the SPIO nanoparticles. In 2014, the first commercially available preclinical MPI scanner (Bruker / Philips) – funded by the German Research Foundation – was installed at the Department of Diagnostic and Interventional Radiology and Nuclear Medicine

SP1 in 60 SecondsVideoarchiv

online seit 02.12.2012

In the first period of the SFB grant, we established the magnetic resonance imaging as a standardized diagnostic technique in Hamburg. We developed new approaches to image the murine biliary system and could show that it is possible to visualise parasitic amebae in the liver, by labeling them with nanoparticles.

In the third funding period, we intend to further explore and advance anatomical and functional magnetic particle imaging of the liver in MRI and MPI to improve the visualization of hepatobiliary pathologies in order to better understand the underlying processes of disease progression.

Related news:

Dieckhoff J, Kaul MG, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H

In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach
Phys Med Biol. 2017 May 7;62(9):3470-3482. doi: 10.1088/1361-6560/aa562d. Epub 2016 Dec 30

Dieckhoff J, Kaul MG, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H

Magnetic Particle Imaging of liver tumors in small animal models
International Journal On Magnetic Particle Imaging, 2017;3

Thiele ND, Wirth JW, Steins D, Koop AC, Ittrich H, Lohse AW, Kluwe J

TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
Sci Rep. 2017 Apr 6;7(1):714. doi: 10.1038/s41598-017-00671-1

Keller S, Ittrich H, Schramm C, Lohse AW, Amling M, Adam G, Yamamura J

Diffusion-weighted MRI for detection of hepatic osteodystrophy in Primary sclerosing cholangitis: a comparison study with dual-energy X-ray absorptiometry
Jpn J Radiol. 2016 Oct;34(10):677-683.

Jung CS, Heine M, Freund B, Reimer R, Koziolek EJ, Kaul MG, Kording F, Schumacher U, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H

Quantitative Activity Measurements of Brown Adipose Tissue at 7 T Magnetic Resonance Imaging After Application of Triglyceride-Rich Lipoprotein 59Fe-Superparamagnetic Iron Oxide Nanoparticle: Intravenous Versus Intraperitoneal Approach
Invest Radiol. 2016 Mar;51(3):194-202. doi: 10.1097/RLI.0000000000000235.