2008

Low recurrence of preexisting extrahepatic malignancies after liver transplantation
Benten D, Sterneck M, Panse J, Rogiers X, Lohse AW.
Liver Transpl. 2008 Jun;14(6):789-98.

Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors
Biburger M, Tiegs G.
J Leukoc Biol. 2008 Jul;84(1):264-79. Epub 2008 Apr 11.

MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection
Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Liu X, Seeberger PH, Jacobs T.
Microbes Infect. 2008 Oct;10(12-13):1259-65. Epub 2008 Jul 22.

Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia
Dandri M, Murray JM, Lutgehetmann M, Volz T, Lohse AW, Petersen J
Hepatology 2008 Oct;48(4):1079-86

An Entamoeba cysteine peptidase specifically expressed during encystation
Ebert F, Bachmann A, Nakada-Tsukui K, Hennings I, Drescher B, Nozaki T, Tannich E, Bruchhaus I.
Parasitol Int. 2008 Dec;57(4):521-4. Epub 2008 Aug 5.

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2×7 as a regulator for intestinal T cell responses
Heiss K, Jänner N, Mähnss B, Schumacher V, Koch-Nolte F, Haag F, Mittrücker HW.
J Immunol. 2008 Sep 15;181(6):3861-9.

Mycophenolate mofetil as second line therapy in autoimmune hepatitis?
Hennes EM, Oo YH, Schramm C, Denzer U, Buggisch P, Wiegard C, Kanzler S, Schuchmann M, Boecher W, Galle PR, Adams DH, Lohse AW.
Am J Gastroenterol. 2008 Dec;103(12):3063-70. Epub 2008 Oct 3.

Simplified criteria for the diagnosis of autoimmune hepatitis
Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Bianchi FB, Shibata M, Schramm C, Eisenmann de Torres B, Galle PR, McFarlane I, Dienes HP, Lohse AW; International Autoimmune Hepatitis Group.
Hepatology. 2008 Jul;48(1):169-76.

Significance of autoantibodies
Herkel J, Lohse AW.
Hepatology. 2008 Mar;47(3):786-8. No abstract available.

P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg
Huber S, Schrader J, Fritz G, Presser K, Schmitt S, Waisman A, Lüth S, Blessing M, Herkel J, Schramm C.
PLoS One. 2008 Oct 1;3(10):e3302.

Post-translational modification of {alpha}-dystroglycan is not critical for lymphocytic choriomeningitis virus receptor function in vivo.
Imperiali M, Spörri R, Hewitt J, Oxenius A.
J Gen Virol. 2008 Nov;89(Pt 11):2713-22.

Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine
Jänner N, Hahnke K, Mollenkopf HJ, Steinhoff U, Kaufmann SH, Mittrücker HW.
Immunology. 2008 Sep;125(1):38-47. Epub 2008 Feb 22.

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM.
J Virol. 2008 Mar;82(6):3154-60. Epub 2007 Dec 26.

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM.
Hepatology. 2008 Dec;48(6):1769-78.

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes
Kursar M, Jänner N, Pfeffer K, Brinkmann V, Kaufmann SH, Mittrücker HW.
Eur J Immunol. 2008 Jan;38(1):127-38.

The role of negative costimulators during parasitic infections.
Lepenies B, Jacobs T.
Endocr Metab Immune Disord Drug Targets. 2008 Dec;8(4):279-88. Review.

Attenuated recombinant Yersinia as live oral vaccine carrier to protect against amoebiasis
Lotter H, Rüssmann H, Heesemann J, Tannich E.
Int J Med Microbiol. 2008 Jan;298(1-2):79-86. Epub 2007 Sep 27. Review.

Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis
Lüth S, Herkel J, Kanzler S, Frenzel C, Galle PR, Dienes HP, Schramm C, Lohse AW.
J Clin Gastroenterol. 2008 Sep;42(8):926-30.

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
Lüth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Brück W, Wraith DC, Herkel J, Lohse AW.
J Clin Invest. 2008 Oct;118(10):3403-10.

Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication
Lutgehetmann M, Volzt T, Quaas A, Zankel M, Fischer C, Dandri M, Petersen J.
Antivir Ther. 2008;13(1):57-66.

Plasmodium pre-erythrocytic stages: what’s new?
Ménard R, Heussler V, Yuda M, Nussenzweig V.
Trends Parasitol. 2008 Dec;24(12):564-9. Epub 2008 Oct 17. Review.

Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis
Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B.
Gastroenterology. 2008 Dec;135(6):2107-18. Epub 2008 Jul 31.

IL-6/IL-6R axis plays a critical role in acute kidney injury
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH.
J Am Soc Nephrol. 2008 Jun;19(6):1106-15. Epub 2008 Mar 12.

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
Petersen J, Dandri M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S
Nat Biotechnol 2008 Mar;26(3):335-41

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J.
Blood. 2008 Feb 1;111(3):1021-8. Epub 2007 Nov 7.

Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
Rehr M, Cahenzli J, Haas A, Price DA, Gostick E, Huber M, Karrer U, Oxenius A.
J Virol. 2008 Apr;82(7):3391-404. Epub 2008 Jan 16.

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice
Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D, Meissnitzer M, Tasika E, Tannapfel A, Tiegs G.
Int J Cancer. 2008 Sep 15;123(6):1269-77.

Expression and processing of Plasmodium berghei SERA3 during liver stages.
Schmidt-Christensen A, Sturm A, Horstmann S, Heussler VT.
Cell Microbiol. 2008 Aug;10(8):1723-34. Epub 2008 Apr 17.

Sorafenib-induced liver failure
Schramm C, Schuch G, Lohse AW.
Am J Gastroenterol. 2008 Aug;103(8):2162-3.:http://www.ncbi.nlm.nih.gov/pubmed/18796127

Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis
Siebler J, Wirtz S, Frenzel C, Schuchmann M, Lohse AW, Galle PR, Neurath MF.
J Immunol. 2008 Jan 1;180(1):30-3.

Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid
Tartz S, Rüssmann H, Kamanova J, Sebo P, Sturm A, Heussler V, Fleischer B, Jacobs T.
Vaccine. 2008 Nov 5;26(47):5935-43. Epub 2008 Sep 17.

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J.
J Biol Chem. 2008 Oct 3;283(40):27200-7. Epub 2008 Jul 23.

Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A.
Thieringer F, Maass T, Czochra P, Klopcic B, Conrad I, Friebe D, Schirmacher P, Lohse AW, Blessing M, Galle PR, Teufel A, Kanzler S.
Gene. 2008 Oct 15;423(1):23-8. Epub 2008 Jun 10.

CCR5 deficiency aggravates crescentic glomerulonephritis in mice
Turner JE, Paust HJ, Steinmetz OM, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker HW, Stahl RA, Panzer U.
J Immunol. 2008 Nov 1;181(9):6546-56.

Autonomic renal denervation ameliorates experimental glomerulonephritis
Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G.
J Am Soc Nephrol. 2008 Jul;19(7):1371-8. Epub 2008 Apr 9.

Unmasking autoimmune hepatitis under immunomodulatory treatment of multiple sclerosis—not only beta interferon
von Kalckreuth V, Lohse AW, Schramm C.
Am J Gastroenterol. 2008 Aug;103(8):2147-8; author reply 2148.