2011

B and T Lymphocyte Attenuator Restricts the Protective Immune Response against Experimental Malaria
Adler G, Steeg C, Pfeffer K, Murphy TL, Murphy KM, Langhorne J, Jacobs T
J Immunol. 2011 Oct 12. [Epub ahead of print]

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH.
Crit Care Med. 2011 Jun;39(6):1407-13.

Brown adipose tissue activity controls triglyceride clearance
Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J
Nat Med. 2011 Feb;17(2):200-5. Epub 2011 Jan 23.

Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells
Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Günes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brümmendorf TH.
Exp Hematol. 2011 Jan;39(1):66-76.e1-2. Epub 2010 Oct 30.

Scavenger receptor CD36 mediates uptake of high density lipoproteins by tissues in mice and by cultured cells
Brundert M, Heeren J, Merkel M, Carambia A, Herkel J, Groitl P, Dobner T, Ramakrishnan R, Moore KJ, Rinninger F
J Lipid Res 2011 Jan 9. [Epub ahead of print]

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer
Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8

PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication
Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD
J Cell Sci. 2011 Jan 15;124(Pt 2):280-91. Epub 2010 Dec 20.

CXCR3 Deficiency Exacerbates Liver Disease and Abrogates Tolerance in a Mouse Model of Immune-Mediated Hepatitis
Erhardt A, Wegscheid C, Claass B, Carambia A, Herkel J, Mittrücker HW, Panzer U, Tiegs G.
J Immunol. 2011 Mar 25. [Epub ahead of print]

Control of TH17 cells occurs in the small intestine
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA
Nature. 2011 Jul 17;475(7357):514-8.

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J
J Biol Chem. 2011 Apr 29;286(17):14804-11. Epub 2011 Mar 15.

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol. 2011 Jan 15;186(2):1199-208. Epub 2010 Dec 10.

Let it B in viral hepatitis?
Herkel J, Carambia A
J Hepatol. 2011 Jan 14. [Epub ahead of print]

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
Huber S, Gagliani N, Esplugues E, O’Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA
Immunity. 2011 Apr 22;34(4):554-65.

Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells
Huber S, Schramm C
Crit Rev Immunol. 2011;31(1):53-60.

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F, Vermeire S, Henckaerts L, Wijmenga C, Ponsioen CY, Schreiber S, Karlsen TH, Franke A, Weersma RK
Hepatology. 2011 Mar 21. doi: 10.1002/hep.24307. [Epub ahead of print]

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Jones SA, Scheller J, Rose-John S
J Clin Invest. 2011, accepted

Memory/effector (CD45RB) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O’Connor W Jr, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA
J Exp Med. 2011 May 9;208(5):1027-40.

Transcription factor Fra-1 induces cholangitis and liver fibrosis
Kireva T, Erhardt A, Tiegs G, Tilg H, Denk H, Haybaeck J, Aigner E, Moschen A, Distler JH, Schett G, Zwerina J
Hepatology. 2011 Apr;53(4):1287-97. doi: 10.1002/hep.24175.

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell. 2011 Apr 12;19(4):456-69.

IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH
Cancer Res. 2011 Jan 15;71(2):424-34. Epub 2010 Dec 1.

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution
Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J.
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20. Epub 2010 Oct 30.

Chronic inflammatory interferon{gamma}-signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis
Luth S, Schrader J, Zander S, Carambia A, Buchkremer J, Huber S, Reifenberg K, Yamamura KI, Schirmacher P, Lohse AW, Herkel J
Cancer Res. 2011 Apr 21. [Epub ahead of print]

Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J
Biochim Biophys Acta. 2011 Mar;1812(3):290-301. Epub 2010 Dec 2.

Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape
Martin-Jaular L, Ferrer M, Calvo M, Rosanas-Urgell A, Kalko S, Graewe S, Soria G, Cortadellas N, Ordi J, Planas A, Burns J, Heussler V, Del Portillo HA
Cell Microbiol. 2011 Jan;13(1):109-22. doi: 10.1111/j.1462-5822.2010.01523.x. Epub 2010 Oct 1.

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH
Nat Genet. 2011 Jan;43(1):17-9. Epub 2010 Dec 12.

Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol. 2011 May;54(5):922-9. Epub 2010 Oct 31.

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis
Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G
Kidney Int. 2011 Apr 27. [Epub ahead of print]

Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT
Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G
Int J Oncol. 2011 May 10. doi: 10.3892/ijo.2011.1037. [Epub ahead of print]

ADAM17: a molecular switch to control inflammation and tissue regeneration
Scheller J, Chalaris A, Garbers C, Rose-John S
Trends Immunol. 2011, in press

The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S.
Biochim Biophys Acta. 2011 May;1813(5):878-88. Epub 2011 Feb 4.

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages
Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S
J Clin Invest. 2011 May 2;121(5):1692-708. doi: 10.1172/JCI42540. Epub 2011 Apr 25.

Role of mycophenolate mofetil in the treatment of autoimmune hepatitis
Schramm C, Lohse AW
J Hepatol. 2011 Jan 28. [Epub ahead of print]

Rapid quantification of telomerase activity employing an improved real-time telomeric repeat amplification protocol in clinical tissue samples eliminates interference by PCR inhibitors
Schriefer P, Günes C, Wege H
J Cancer Sci Ther 2011; 3: 176-180

Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil
Strasak AM, Kim AY, Lauer GM, de Sousa PS, Ginuino CF, Fernandes CA, Velloso CE, de Almeida AJ, de Oliveira JM, Yoshida CF, Schulze zur Wiesch J, Paranhos-Baccalá G, Lang S, Brant LJ, Ulmer H, Strohmaier S, Kaltenbach L, Lampe E, Lewis-Ximenez LL
BMC Infect Dis. 2011 Jan 12;11:15.

SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration
Thill M, Berna MJ, Kunst F, Wege H, Strunnikova NV, Gordiyenko N, Grierson R, Richard G, Csaky KG
Molecular Vision 2011; 17:85-98

RGB marking facilitates multicolor clonal cell tracking
Weber K, Thomaschewski M, Warlich M, Volz T, Cornils K, Niebuhr B, Täger M, Lütgehetmann M, Pollok JM, Stocking C, Dandri M, Benten D, Fehse B.
Nat Med. 2011 Mar 27. [Epub ahead of print]

Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes
Wege H, Heim D, Lütgehetmann M, Dierlamm J, Lohse AW, Brümmendorf TH.
Mol Cancer Res. 2011 Sep;9(9):1222-31

Drug induced liver injury and its relationship to autoimmune hepatitis
Weiler-Normann C, Schramm C
J Hepatol. 2011 Mar 8. [Epub ahead of print]

Pregnancy in primary sclerosing cholangitis
Wellge BE, Sterneck M, Teufel A, Rust C, Franke A, Schreiber S, Berg T, Günther R, Kreisel W, Zu Eulenburg C, Braun F, Beuers U, Galle PR, Lohse AW, Schramm C
Gut. 2011 Feb 21. [Epub ahead of print]

RAS/MAPK signalling modulates protein stability and cell surface expression of SR-BI
Wood P, Mulay V, Darabi M, Chan KC, Heeren J, Pol A, Lambert G, Rye KA, Enrich C, Grewal T
J Biol Chem. 2011 Apr 27. [Epub ahead of print]