2012

Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice
Barikbin R, Neureiter D, Wirth J, Erhardt A, Schwinge D, Kluwe J, Schramm C, Tiegs G, Sass G.
Hepatology. 2012 Feb;55(2):553-62. doi: 10.1002/hep.24711.

A new, powerful player in lipoprotein metabolism: brown adipose tissue
Bartelt A, Merkel M, Heeren J.
J Mol Med (Berl). 2012 Jan 10. [Epub ahead of print]

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
Belloni L, Allweiss L, Guerrieri F, Pediconi N, Volz T, Pollicino T, Petersen J, Raimondo G, Dandri M, Levrero M.
J Clin Invest. 2012 Feb 1;122(2):529-37. doi: 10.1172/JCI58847. Epub 2012 Jan 17.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
Carambia A, Frenzel C, Bruns OT, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse AW, Herkel J.
J Hepatol. 2012 Sep 15. pii: S0168-8278(12)00698-8. doi: 10.1016/j.jhep.2012.09.008. [Epub ahead of print]

Th17 cells bound for the liver: Group tourists or private travellers?
Carambia A, Herkel J.
J Hepatol. 2012 Aug 16. [Epub ahead of print]

Plasticity and cross-talk of Interleukin 6-type cytokines
Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J.
Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. Epub 2012 May 15.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA.
Nature. 2012 Oct 17. doi: 10.1038/nature11535.

SOCS3 promotes Interleukin-17 expression of human T cells
Kleinsteuber K, Heesch K, Schattling S, Sander-Juelch C, Mock U, Riecken K, Fehse B, Fleischer B, Jacobsen M.
Blood. 2012 Oct 1. [Epub ahead of print]

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration
Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T, Breloer M.
Eur J Immunol. 2012 Apr;42(4):890-900. doi: 10.1002/eji.201141955. Epub 2012 Jan 19.

Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E
Laatsch A, Panteli M, Sornsakrin M, Hoffzimmer B, Grewal T, Heeren J.
PLoS One. 2012;7(1):e29385. Epub 2012 Jan 4.

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
Lütgehetmann M, Mancke LV, Volz T, Helbig M, Allweiss L, Bornscheuer T, Pollok JM, Lohse AW, Petersen J, Urban S, Dandri M.
Hepatology. 2012 Mar;55(3):685-94. doi: 10.1002/hep.24758. Epub 2012 Jan 30.

Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U.
RNA Biol. 2012 Jan;9(1):67-80. Epub 2012 Jan 1.

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
Peiseler M, Sebode M, Franke B, Wortmann F, Schwinge D, Quaas A, Baron U, Olek S, Wiegard C, Lohse AW, Weiler-Normann C, Schramm C, Herkel J.
J Hepatol. 2012 Mar 13. [Epub ahead of print]

Reply to: “Regulatory T cell defects in autoimmune hepatitis”
Peiseler M, Sebode M, Schramm C, Herkel J.
J Hepatol. 2012 Jul 28. [Epub ahead of print]

Reply to: “T regulatory cell number and function: The autoimmune traits in liver diseases”
Peiseler M, Sebode M, Schramm C, Herkel J.
J Hepatol. 2012 Aug 23. pii: S0168-8278(12)00646-0. doi: 10.1016/j.jhep.2012.08.014. [Epub ahead of print]

Reply to: “Regulatory T cells in autoimmune hepatitis”
Peiseler M, Sebode M, Schramm C, Herkel J.
J Hepatol. 2012 Oct;57(4):933-4. Epub 2012 Jun 28.

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action
Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J.
PLoS One. 2012;7(4):e34787. Epub 2012 Apr 24.

Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
Schrader J, Herkel J.
Oncoimmunology. 2012 Mar 1;1(2):222-223.

Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K.
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):281-90. Epub 2011 Nov 10.

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM.
J Exp Med. 2012 Jan 16;209(1):61-75. Epub 2012 Jan 2.

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J.
J Biol Chem. 2012 Apr 20;287(17):13743-51.

P. berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8 memory T cells
Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T.
Eur J Immunol. 2012 Dec 10. doi: 10.1002/eji.201142262. [Epub ahead of print]

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with Hepatitis B Virus
Volz T, Allweiss L, M Barek MB, Warlich M, Lohse AW, Pollok JM, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M.
J Hepatol. 2012 Dec 12. pii: S0168-8278(12)00956-7. doi: 10.1016/j.jhep.2012.12.008. [Epub ahead of print]

Hitting a complex target: an update on interleukin-6 trans-signalling
Waetzig GH, Rose-John S.
Expert Opin Ther Targets. 2012 Feb;16(2):225-36.

RGB marking with lentiviral vectors for multicolor clonal cell tracking
Weber K, Thomaschewski M, Benten D, Fehse B.
Nat Protoc. 2012 Apr 5;5(4):839-49. doi: 10.1038/nprot.2012.026.

Therapeutic blockade of interleukin-6 in chronic inflammatory disease
Yamamoto K, Rose-John S.
Clin Pharmacol Ther. 2012 Apr;91(4):574-6. doi: 10.1038/clpt.2012.11.