2013

Inflammation induced hepatocellular carcinoma is dependent on CCR5
Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, Klein S, Goldenberg D, Axelrod J, Pikarsky E, Abramovitch R, Zeira E, Galun E, Peled A.
Hepatology. 2013 Sep;58(3):1021-30. doi: 10.1002/hep.26403. Epub 2013 Jul 12.

Influenza virus-specific TCR-transduced T cells as a model for adoptive immunotherapy
Berdien B, Reinhard H, Meyer S, Spöck S, Kröger N, Atanackovic D, Fehse B.
Hum Vaccin Immunother. 2013 Jun;9(6):1205-16. doi: 10.4161/hv.24051. Epub 2013 Feb 21.

Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G.
J Immunol. 2013 Dec 1;191(11):5574-82. doi: 10.4049/jimmunol.1300826. Epub 2013 Oct 18.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
Carambia A, Frenzel C, Bruns OT, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse AW, Herkel J.
J Hepatol. 2013 Jan;58(1):112-8. doi: 10.1016/j.jhep.2012.09.008. Epub 2012 Sep 16.

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector
Cornils K, Bartholomae CC, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B.
Exp Hematol. 2013 Jan;41(1):28-38.e3. doi: 10.1016/j.exphem.2012.09.003. Epub 2012 Sep 16.

Primary Sclerosing Cholangitis and Cholangiocarcinoma: Pathogenesis and Modes of Diagnostics
Ehlken H, Schramm C
Dig Dis. 2013;31(1):118-25. doi: 10.1159/000347206. Epub 2013 Jun 17.

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing L, Scherer T, Tödter K, Knippschild U, Greve JW, Buurman WA, Pinnschmidt HO, Rensen SS, Wolf AM, Bartelt A, Heeren J, Buettner C, Scheja L.

Nat Commun. 2013;4:1528. doi: 10.1038/ncomms2537.

Imaging of the murine biliopancreatic tract at 7 tesla: Technique and results in a model of primary sclerosing cholangitis
Ernst TM, Schwinge D, Raabe N, Daubmann A, Kaul MG, Adam G, Schramm C, Ittrich H.
J Magn Reson Imaging. 2013 Nov 13. doi: 10.1002/jmri.24475. [Epub ahead of print]

The regenerative activity of interleukin-6
Galun E, Rose-John S.
Methods Mol Biol. 2013;982:59-77. doi: 10.1007/978-1-62703-308-4_4.

TNFα-mediated liver destruction by kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H.
PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096. Epub 2013 Jan 3.

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW.

J Immunol. 2013 Jan 15;190(2):703-11. doi: 10.4049/jimmunol.1201044. Epub 2012 Dec 12.

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy
Ittrich H, Peldschus K, Raabe N, Kaul M, Adam G.
Rofo. 2013 Dec;185(12):1149-66. doi: 10.1055/s-0033-1335438. Epub 2013 Sep 5.

Control of human viral infections by natural killer cells
Jost S, Altfeld M.
Annu Rev Immunol. 2013;31:163-94. doi: 10.1146/annurev-immunol-032712-100001. Epub 2013 Jan 3.

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis
Katt J, Schwinge D, Schoknecht T, Quaas A, Sobottka I, Burandt E, Becker C, Neurath MF, Lohse AW, Herkel J, Schramm C.
Hepatology. 2013 Sep;58(3):1084-93. doi: 10.1002/hep.26447. Epub 2013 Jul 30.

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC.
Nature. 2013 Feb 7;494(7435):111-5. doi: 10.1038/nature11793

CD38 controls the innate immune response against Listeria monocytogenes
Lischke T, Heesch K, Schumacher V, Schneider M, Haag F, Koch-Nolte F, Mittrücker HW.
Infect Immun. 2013 Nov;81(11):4091-9. doi: 10.1128/IAI.00340-13. Epub 2013 Aug 26.

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJ, Sterneck M, Teufel A, Mason AL, Saarela J, Leppa V, Dorfman R, Alvaro D, Floreani A, Onengut-Gumuscu S, Rich SS, Thompson WK, Schork AJ, Næss S, Thomsen I, Mayr G, König IR, Hveem K, Cleynen I, Gutierrez-Achury J, Ricaño-Ponce I, van Heel D, Björnsson E, Sandford RN, Durie PR, Melum E, Vatn MH, Silverberg MS, Duerr RH, Padyukov L, Brand S, Sans M, Annese V, Achkar JP, Boberg KM, Marschall HU, Chazouillères O, Bowlus CL, Wijmenga C, Schrumpf E, Vermeire S, Albrecht M; The UK-PSCSC Consortium; The International IBD Genetics Consortium, Rioux JD, Alexander G, Bergquist A, Cho J, Schreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN; The International PSC Study Group, Franke A, Anderson CA, Karlsen TH.
Nat Genet. 2013 Jun;45(6):670-5. doi: 10.1038/ng.2616. Epub 2013 Apr 21.

Not all PBC is the same!
Lohse AW, Weiler-Normann C.
Gastroenterology. 2013 Mar;144(3):494-7. doi: 10.1053/j.gastro.2013.01.032. Epub 2013 Jan 23.

Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells
Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E.
PLoS One. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694. Epub 2013 Feb 12.

Overexpression of Specific Cysteine Peptidases Confers Pathogenicity to a Nonpathogenic Entamoeba histolytica Clone
Matthiesen J, Bär AK, Bartels AK, Marien D, Ofori S, Biller L, Tannich E, Lotter H, Bruchhaus I.
MBio. 2013 Mar 26;4(2). pii: e00072-13. doi: 10.1128/mBio.00072-13.

A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine
Nagel A, Prado M, Heitmann A, Tartz S, Jacobs T, Deschermeier C, Helm S, Stanway R, Heussler V.
Int J Parasitol. 2013 May;43(6):503-14. doi: 10.1016/j.ijpara.2013.01.010. Epub 2013 Mar 13.

In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN.
Clin Exp Pharmacol Physiol. 2013 Apr;40(4):262-72. doi: 10.1111/1440-1681.12064.

Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis
Potikha T, Stoyanov E, Pappo O, Frolov A, Mizrahi L, Olam D, Shnitzer-Perlman T, Weiss I, Barashi N, Peled A, Sass G, Tiegs G, Poirier F, Rabinovich GA, Galun E, Goldenberg D.
Hepatology. 2013 Jul;58(1):192-204. doi: 10.1002/hep.26335. Epub 2013 May 27.

Infiltration of peritumoural but tumour-free parenchyma with IgG4-positive plasma cells in hilar cholangiocarcinoma and pancreatic adenocarcinoma
Resheq YJ, Quaas A, von Renteln D, Schramm C, Lohse AW, Lüth S.

Dig Liver Dis. 2013 Oct;45(10):859-65. doi: 10.1016/j.dld.2013.03.007. Epub 2013 Apr 19.

Reversal of chronic to resolved infection by IL-10 blockade is LCMV strain dependent
Richter K, Perriard G, Oxenius A.
Eur J Immunol. 2013 Mar;43(3):649-54. doi: 10.1002/eji.201242887. Epub 2013 Jan 25.

gp130 activation is regulated by D2-D3 interdomain connectivity
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D.

Biochem J. 2013 Mar 15;450(3):487-96. doi: 10.1042/BJ20121660.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker H-W, Rabe B, Rose-John S, Chalaris A.
Biochim Biophys Acta. 2013 Dec;1833(12):3355-67. doi: 10.1016/j.bbamcr.2013.10.005. Epub 2013 Oct 14.

Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8 memory T cells
Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T.

Eur J Immunol. 2013 Mar;43(3):693-704. doi: 10.1002/eji.201142262. Epub 2013 Jan 18.

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Volz T, Allweiss L, M Barek MB, Warlich M, Lohse AW, Pollok JM, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M.

J Hepatol. 2013 May;58(5):861-7. doi: 10.1016/j.jhep.2012.12.008. Epub 2012 Dec 13.

Autoimmune hepatitis: a life-long disease
Weiler-Normann C, Lohse AW.
J Hepatol. 2013 Jan;58(1):5-7. doi: 10.1016/j.jhep.2012.10.007. Epub 2012 Oct 11.

Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis
Weiler-Normann C, Schramm C, Quaas A, Wiegard C, Glaubke C, Pannicke N, Möller S, Lohse AW.
J Hepatol. 2013 Mar;58(3):529-34. doi: 10.1016/j.jhep.2012.11.010. Epub 2012 Nov 21.

Reply to: “Use of TNFα antagonists in refractory AIH: Revealing the unforeseen”
Weiler-Normann C, Schramm C, Lohse AW.
J Hepatol. 2013 Mar 23. pii: S0168-8278(13)00195-5. doi: 10.1016/j.jhep.2013.03.017. [Epub ahead of print]