2014

Allweiss L, Volz T, Lütgehetmann M, Giersch K, Bornscheuer T, Lohse AW, Petersen J, Ma H, Klumpp K, Fletcher SP, Dandri M

Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
J Hepatol. 2014 Mar;60(3):500-7. doi: 10.1016/j.jhep.2013.10.021. Epub 2013 Oct 26.

Anton KA, Sinclair J, Ohoka A, Kajita M, Ishikawa S, Benz PM, Renne T, Balda M, Jorgensen C, Matter K, Fujita Y

PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium
J Cell Sci. 2014 Aug 15;127(Pt 16):3425-33. doi: 10.1242/jcs.149674. Epub 2014 Jun 24.

Bartelt A, Beil FT, Müller B, Koehne T, Yorgan TA, Heine M, Yilmaz T, Rüther W, Heeren J, Schinke T, Niemeier A

Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity
Bone. 2014 May;62:90-8. doi: 10.1016/j.bone.2014.01.001. Epub 2014 Jan 16.

Beisel C, Heuer M, Otto B, Jochum J, Schmiedel S, Hertling S, Degen O, Lüth S, van Lunzen J, Schulze Zur Wiesch J

German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients
AIDS Res Ther. 2014 Jul 1;11:16. doi: 10.1186/1742-6405-11-16. eCollection 2014.

Berdien B, Mock U, Atanackovic D, Fehse B

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer
Gene Ther. 2014 Jun;21(6):539-48. doi: 10.1038/gt.2014.26. Epub 2014 Mar 27.

Bernin H, Lotter H

Sex bias in the outcome of human tropical infectious diseases: influence of steroid hormones
J Infect Dis. 2014 Jul 15;209 Suppl 3:S107-13. doi: 10.1093/infdis/jit610. Review.

Bernin H, Marggraff C, Jacobs T, Brattig N, An L, Blessmann J, Lotter H

Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex
BMC Infect Dis. 2014 Nov 25;14(1):621. [Epub ahead of print]

Biller L, Matthiesen J, Kühne V, Lotter H, Handal G, Nozaki T, Saito-Nakano Y, Schümann M, Roeder T, Tannich E, Krause E, Bruchhaus I

The cell surface proteome of Entamoeba histolytica
Mol Cell Proteomics. 2014 Jan;13(1):132-44. doi: 10.1074/mcp.M113.031393. Epub 2013 Oct 17.

Carambia A, Freund B, Schwinge D, Heine M, Laschtowitz A, Huber S, Wraith DC, Korn T, Schramm C, Lohse AW, Heeren J, Herkel J

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells
J Hepatol. 2014 Sep;61(3):594-9. doi: 10.1016/j.jhep.2014.04.027. Epub 2014 May 2.

Carambia A, Herkel J

Liver sinusoidal cells collecting MHC-I molecules: You can’t get enough of a good thing
J Hepatol. 2014 Sep;61(3):464-5. doi: 10.1016/j.jhep.2014.06.003. Epub 2014 Jun 11.

Carambia A, Herkel J

Deciphering the highway code for lymphocyte traffic along the gut – liver axis
J Hepatol. 2014 Jun;60(6):1110-1. doi: 10.1016/j.jhep.2014.02.027. Epub 2014 Mar 6.

Condiotti R, Goldenberg D, Giladi H, Schnitzer-Perlman T, Waddington S, Buckley SM, Heim D, Cheung W, Themis M, Charles C, Simerzin A, Osejindu E, Wege H, Themis M, Galun E.

Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature
Mol Ther. 2014 Jan;22(1):59-68. doi: 10.1038/mt.2013.193. Epub 2013 Aug 28.

Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B

Multiplexing clonality: Combining RGB-marking and genetic barcoding
Nucleic Acids Res. 2014 Apr;42(7):e56. doi: 10.1093/nar/gku081. Epub 2014 Jan 29.

Dandri M, Lütgehetmann M

Mouse models of hepatitis B and delta virus infection
J Immunol Methods. 2014 Aug;410:39-49. doi: 10.1016/j.jim.2014.03.002. Epub 2014 Mar 12.

Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U

GP130 activation induces myeloma and collaborates with MYC
J Clin Invest. 2014 Dec;124(12):5263-74. doi:10.1172/JCI69094. Epub 2014 Nov 10.

Eberhard JM, Hartjen P, Kummer S, Schmidt RE, Bockhorn M, Lehmann C, Balagopal A, Hauber J, van Lunzen J, Schulze zur Wiesch J

CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression
PLoS One. 2014 Nov 4;9(11):e111323. doi:10.1371/journal.pone.0111323. eCollection 2014.

Ella E, Heim D, Stoyanov E, Harari-Steinfeld R, Steinfeld I, Pappo O, Perlman TS, Nachmansson N, Rivkin L, Olam D, Abramovitch R, Wege H, Galun E, Goldenberg D

Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver
Oncotarget. 2014 Nov 15;5(21):10318-31.

Ernst TM, Schwinge D, Raabe N, Daubmann A, Kaul MG, Adam G, Schramm C, Ittrich H

Imaging of the murine biliopancreatic tract at 7 Tesla: technique and results in a model of primary sclerosing cholangitis
J Magn Reson Imaging. 2014 Dec;40(6):1355-64. doi: 10.1002/jmri.24475. Epub 2013 Nov 13

Espinoza Mora Mdel R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B, Jacobs T

Depletion of Regulatory T Cells Augments a Vaccine-Induced T Effector Cell Response against the Liver-Stage of Malaria but Fails to Increase Memory
PLoS One. 2014 Aug 12;9(8):e104627. doi: 10.1371/journal.pone.0104627. eCollection 2014.

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M; International PSC Study Group (IPSCSG)

Characterization of animal models for primary sclerosing cholangitis (PSC)
J Hepatol. 2014 Jun;60(6):1290-303. doi: 10.1016/j.jhep.2014.02.006. Epub 2014 Feb 19.

Giersch K, Helbig M, Volz T, Allweiss L, Mancke LV, Lohse AW, Polywka S, Pollok JM, Petersen J, Taylor J, Dandri M, Lütgehetmann M

Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection

J Hepatol. 2014 Mar;60(3):538-44. doi: 10.1016/j.jhep.2013.11.010. Epub 2013 Nov 23.

Gomez-Nicola D, Riecken K, Fehse B, Perry VH

In-vivo RGB marking and multicolour single-cell tracking in the adult brain
Sci Rep. 2014 Dec 22;4:7520. doi: 10.1038/srep07520

Heesch K, Raczkowski F, Schumacher V, Hünemörder S, Panzer U, Mittrücker HW

The function of the chemokine receptor CXCR6 in the T cell response of mice against Listeria monocytogenes
PLoS One. 2014 May 15;9(5):e97701. doi: 10.1371/journal.pone.0097701. eCollection 2014. PMID: 24832098

Heim D, Cornils K, Schulze K, Fehse B, Lohse AW, Brümmendorf AW, Wege H

Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
Oncogene. 2014 Jan 13. doi: 10.1038/onc.2013.551. [Epub ahead of print]

Heine M, Bartelt A, Bruns OT, Bargheer D, Giemsa A, Freund B, Scheja L, Waurisch C, Eychmüller A, Reimer R, Weller H, Nielsen P, Heeren J

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver
Beilstein J Nanotechnol. 2014 Sep 2;5:1432-40. doi: 10.3762/bjnano.5.155. eCollection 2014.

Homs M, Giersch K, Blasi M, Lütgehetmann M, Buti M, Esteban R, Dandri M, Rodriguez-Frias F

Relevance of a full-length genomic RNA standard and a thermal-shock step for optimal hepatitis delta virus quantification
J Clin Microbiol. 2014 Sep;52(9):3334-8. doi: 10.1128/JCM.00940-14. Epub 2014 Jul 2.

John C, Werner P, Worthmann A, Wegner K, Tödter K, Scheja L, Rohn S, Heeren J, Fischer M

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids
J Chromatogr A. 2014 Dec 5;1371:184-95. doi: 10.1016/j.chroma.2014.10.064. Epub 2014 Oct 29.

Kuijpers MJ, van der Meijden PE, Feijge MA, Mattheij NJ, May F, Govers-Riemslag J, Meijers JC, Heemskerk JW, Renné T, Cosemans JM

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques
Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1674-80. doi: 10.1161/ATVBAHA.114.303315. Epub 2014 May 22.

Mittrücker HW, Seidel D, Bland PW, Zarzycka A, Kaufmann SH, Visekruna A, Steinhoff U

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection
Eur J Immunol. 2014 Jun;44(6):1710-5. doi: 10.1002/eji.201343927. Epub 2014 Mar 20.

Mock U, Riecken K, Berdien B, Qasim W, Chan E, Cathomen T, Fehse B

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases
Sci Rep. 2014 Sep 18;4:6409. doi: 10.1038/srep06409.

Oehler N, Volz T, Bhadra OD, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok JM, Lohse AW, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of the bile acid metabolism
Hepatology. 2014 Nov;60(5):1483-93. doi: 10.1002/hep.27159. Epub 2014 May 19.

Sebode M, Peiseler M, Franke B, Schwinge D, Schoknecht T, Wortmann F, Quaas A, Petersen BS, Ellinghaus E, Baron U, Olek S, Wiegard C, Weiler-Normann C, Lohse AW, Herkel J, Schramm C

Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
J Hepatol. 2014 May;60(5):1010-6. doi: 10.1016/j.jhep.2013.12.027. Epub 2014 Jan 8.

Sebode M, Peiseler M, Weiler-Normann C, Schramm C, Lohse AW, Herkel J

Phenotypic alterations of regulatory T cells in autoimmune hepatitis: causal or associated with treatment and remission?
Hepatology. 2014 Jul 12. doi: 10.1002/hep.27301. [Epub ahead of print]

Scheja L, Kluwe J

Arginine and NASH – do macrophages deliver the first hit?
J Hepatol. 2014 Nov 8. pii: S0168-8278(14)00816-2. doi: 10.1016/j.jhep.2014.11.001. [Epub ahead of print]

Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S.

Oncogenic deletion mutants of gp130 signal from intracellular compartments
J Cell Sci. 2014 Jan 15;127(Pt 2):341-53. doi: 10.1242/jcs.130294. Epub 2013 Nov 8.

Schramm C, Lohse AW

Autoimmune hepatitis on the rise
J Hepatol. 2014 Mar;60(3):478-9. doi: 10.1016/j.jhep.2013.11.025. Epub 2013 Dec 1.

Schramm C, Wahl I, Weiler-Normann C, Voigt K, Wiegard C, Glaubke C, Brähler E, Löwe B, Lohse AW, Rose M

Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis
J Hepatol. 2014 Mar;60(3):618-24. doi: 10.1016/j.jhep.2013.10.035. Epub 2013 Nov 14.

Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A

Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding
J Biol Chem. 2014 Jan 31;289(5):3080-93. doi: 10.1074/jbc.M113.536847. Epub 2013 Dec 13.

Trautmann T, Kozik JH, Carambia A, Richter K, Lischke T, Schwinge D, Mittrücker HW, Lohse AW, Oxenius A, Wiegard C, Herkel J

CD4+ T-Cell Help Is Required for Effective CD8+ T Cell-Mediated Resolution of Acute Viral Hepatitis in Mice
PLoS One. 2014 Jan 21;9(1):e86348. doi: 10.1371/journal.pone.0086348. eCollection 2014.

Wahl I, Feige A, Löwe B, Weiler-Normann C, Rose M, Lohse AW, Schramm C

Primary Biliary “Cirrhosis”: Time to Replace a Misnomer
Hepatology. 2014 Jun 13. doi: 10.1002/hep.27263. [Epub ahead of print]

Wegscheid C, Karimi K, Tiegs G

Hepatic CD141⁺IFNλ⁺ DC subset: one against all?
J Hepatol. 2014 Jan;60(1):9-11. doi: 10.1016/j.jhep.2013.10.007. Epub 2013 Oct 16.

Weiler-Normann C, Herkel J, Schramm C, Lohse AW

Reply to: “Anti-TNF-induced autoimmune hepatitis”
J Hepatol. 2014 Jul;61(1):170-1. doi: 10.1016/j.jhep.2014.03.008. Epub 2014 Mar 17.

Wuestenberg A, Kah J, Singethan K, Sirma H, Keller AD, Rosal SR, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse AW, Tiegs G, Sass G

Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin
PLoS ONE 9(5): e96533. doi:10.1371/journal.pone.0096533

Zenouzi R, Weismüller TJ, Hübener P, Schulze K, Bubenheim M, Pannicke N, Weiler-Normann C, Lenzen H, Manns MP, Lohse AW, Schramm C

Low risk of hepatocellular carcinoma in patients with primary sclerosing cholangitis with cirrhosis
Clin Gastroenterol Hepatol. 2014 Oct;12(10):1733-8. doi:10.1016/j.cgh.2014.02.008. Epub 2014 Feb 12.