2016

Ahmed M, Kumar G, Moussa M, Wang Y, Rozenblum N, Galun E, Goldberg SN

Hepatic Radiofrequency Ablation-induced Stimulation of Distant Tumor Growth Is Suppressed by c-Met Inhibition
Radiology. 2016 Apr;279(1):103-17. doi:10.1148/radiol.2015150080. Epub 2015 Sep 29.

Allweiss L, Dandri M

Experimental in vitro and in vivo models for the study of human hepatitis B virus infection
J Hepatol. 2016 Apr;64(1 Suppl):S17-31. doi: 10.1016/j.jhep.2016.02.012. Review.

Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse AW, Polywka S, Pischke S, Herker E, Dandri M, Lütgehetmann M

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
J Hepatol. 2016 May;64(5):1033-40. doi: 10.1016/j.jhep.2016.01.011. Epub 2016 Jan 22.

Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus
Med Microbiol Immunol. 2016 Aug;205(4):321-32. doi: 10.1007/s00430-016-0449-y. Epub 2016 Feb 20.

Bhardwaj S, Ahmad F, Wedemeyer H, Cornberg M, Schulze Zur Wiesch J, van Lunzen J, Sarin SK, Schmidt RE, Meyer-Olson D

Increased CD56 NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype
Virol J. 2016 Apr 18;13(1):67. doi:10.1186/s12985-016-0507-5.

Bierwolf J, Volz T, Lutgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff JC, Dandri M, Pollok JM

Primary human hepatocytes repopulate livers of mice after in vitro culturing and lentiviral-mediated gene transfer
Tissue Eng Part A. 2016 Apr 11. [Epub ahead of print]

Dandri M, Bockmann JH

The challenge of protecting without overprotecting: The two sides of myeloid-derived suppressor cells in hepatitis B viral infection
Hepatology. 2016 Mar;63(3):1043-6. doi: 10.1002/hep.28385. Epub 2016 Jan 14.

Dandri M, Petersen J

Mechanism of Hepatitis B Virus Persistence in Hepatocytes and Its Carcinogenic Potential
Clin Infect Dis. 2016 Jun 1;62 Suppl 4:S281-8. doi: 10.1093/cid/ciw023.

Eberhard JM, Kummer S, Hartjen P, Hüfner A, Diedrich T, Degen O, Lohse AW, van Lunzen J, Wiesch JS

Reduced CD161+MAIT cell frequencies in HCV and HIV/HCV co-infection. Is the liver the heart of the matter?
J Hepatol. 2016 Aug 1. pii:S0168-8278(16)30401-9. doi: 10.1016/j.jhep.2016.07.031. [Epub ahead of print]

Ehlken H, Wroblewski R, Corpechot C, Arrivé L, Lezius S, Hartl J, Denzer UW, Lohse AW, Chazouilleres O, Schramm C

Spleen size for the prediction of clinical outcome in patients with primary sclerosing cholangitis
Gut. 2016 Jul;65(7):1230-2. doi: 10.1136/gutjnl-2016-311452. Epub 2016 Feb 26.

Galun E

Liver inflammation and cancer: The role of tissue microenvironment in generating the tumor-promoting niche (TPN) in the development of hepatocellular carcinoma
Hepatology. 2016 Feb;63(2):354-6. doi: 10.1002/hep.28344. Epub 2015 Dec 18.

Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response
Oncotarget. 2016 Jul 30. doi: 10.18632/oncotarget.10956. [Epub ahead of print]

Horst AK, Neumann K, Diehl L, Tiegs G

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells
Cell Mol Immunol. 2016 May;13(3):277-92. doi: 10.1038/cmi.2015.112. Epub 2016 Apr 4. Review

Jung CS, Heine M, Freund B, Reimer R, Koziolek EJ, Kaul MG, Kording F, Schumacher U, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H

Quantitative Activity Measurements of Brown Adipose Tissue at 7 T Magnetic Resonance Imaging After Application of Triglyceride-Rich Lipoprotein 59Fe-Superparamagnetic Iron Oxide Nanoparticle: Intravenous Versus Intraperitoneal Approach
Invest Radiol. 2016 Mar;51(3):194-202. doi: 10.1097/RLI.0000000000000235.

Kah J, Volz T, Lütgehetmann M, Groth A, Lohse AW, Tiegs G, Sass G, Dandri M

Haem oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Liver Int. 2016 Dec 19. doi:10.1111/liv.13347. [Epub ahead of print]

Keller S, Ittrich H, Schramm C, Lohse AW, Amling M, Adam G, Yamamura J

Diffusion-weighted MRI for detection of hepatic osteodystrophy in Primary sclerosing cholangitis: a comparison study with dual-energy X-ray absorptiometry
Jpn J Radiol. 2016 Oct;34(10):677-683.

Kozik JH, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils
Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.

Labberton L, Kenne E, Long AT, Nickel KF, Di Gennaro A, Rigg RA, Hernandez JS,Butler L, Maas C, Stavrou EX, Renné T

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Nat Commun. 2016 Sep 6;7:12616. doi:10.1038/ncomms12616

Labberton L, Long AT, Gendler SJ, Snozek CL, Stavrou EX, Nickel KF, Maas C, Blankenberg S, Hernandez JS, Renné T

A flow cytometry-based assay for procoagulant platelet polyphosphate
Cytometry B Clin Cytom. 2016 Nov 4. doi:10.1002/cyto.b.21492. [Epub ahead of print]

Long AT, Kenne E, Jung R, Fuchs TA, Renné T

Contact system revisited: an interface between inflammation, coagulation, and innate immunity
J Thromb Haemost. 2016 Mar;14(3):427-37. doi: 10.1111/jth.13235. Epub 2016 Feb 9. Review.

Lunemann S, Martrus G, Hölzemer A, Chapel A, Ziegler M, Körner C, Beltran WG, Carrington M, Wedemeyer H, Altfeld M

Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C(∗)03:04 and modulate NK cell function

J Hepatol. 2016 Apr 4. pii: S0168-8278(16)30097-6. doi:10.1016/j.jhep.2016.03.016. [Epub ahead of print]

Mackroth MS, Abel A, Steeg C, Schulze Zur Wiesch J, Jacobs T

Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function
PLoS Pathog. 2016 Nov 1;12(11):e1005909. doi: 10.1371/journal.ppat.1005909.

Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker HW

Interferon Regulatory Factor 4 controls T(H1) cell effector function and metabolism
Sci Rep. 2016 Oct 20;6:35521. doi:10.1038/srep35521

Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Bruchhaus I, Lotter H

Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation
PLoS Pathog. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853. eCollection 2016 Aug.

Mock U, Hauber I, Fehse B

Digital PCR to assess gene-editing frequencies (GEF-dPCR) mediated by designer nucleases
Nat Protoc. 2016 Mar;11(3):598-615. doi: 10.1038/nprot.2016.027. Epub 2016 Feb 25.

Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis
Oncotarget. 2016 Mar 1. doi: 10.18632/oncotarget.7836. [Epub ahead of print]

Murray JM, Stancevic O, Lütgehetmann M, Wursthorn K, Petersen J, Dandri M

Variability in long-term hepatitis B virus dynamics under antiviral therapy
J Theor Biol. 2016 Feb 21;391:74-80. doi: 10.1016/j.jtbi.2015.12.005.

Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H

IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage
J Hepatol. 2016 May;64(5):1147-57. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.

Potikha T, Ella E, Cerliani JP, Mizrahi L, Pappo O, Rabinovich GA, Galun E, Goldenberg DS

Galectin-1 is essential for efficient liver regeneration following hepatectomy
Oncotarget. 2016 May 5. doi: 10.18632/oncotarget.9194. [Epub ahead of print]

Rivkin M, Simerzin A, Zorde-Khvalevsky E, Chai C, Yuval JB, Rosenberg N, Harari-Steinfeld R, Schneider R, Amir G, Condiotti R, Heikenwalder M, Weber A, Schramm C, Wege H, Kluwe J, Galun E, Giladi H

Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-derived Erythropoietin and Anemia
Gastroenterology. 2016 Jul 28. pii:S0016-5085(16)34827-2. doi: 10.1053/j.gastro.2016.07.031. [Epub ahead of print]

Scheja L, Heeren J

Metabolic interplay between white, beige, brown adipocytes and the liver
J Hepatol. 2016 May;64(5):1176-86. doi:10.1016/j.jhep.2016.01.025. Epub 2016 Jan 30. Review.

Scherer T, Lindtner C, O’Hare J, Hackl M, Zielinski E, Freudenthaler A, Baumgartner-Parzer S, Tödter K, Heeren J, Krššák M, Scheja L, Fürnsinn C, Buettner C

Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain
Diabetes. 2016 Feb 9. pii: db151552. [Epub ahead of print]

Scheurich C, Schulze Zur Wiesch J, Kim AY, Lewis-Ximenez L, Meyer T, Polywka S, Chung RT, Lauer GM

Breadth of the HCV-specific CD4+ T-cell response in spontaneous resolvers is independent of the IL-28 haplotype
J Viral Hepat. 2016 Oct;23(10):831-2. doi: 10.1111/jvh.12560. Epub 2016 Jun 27.

Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains
Biol Chem. 2016 Sep 1;397(9):857-69. doi: 10.1515/hsz-2016 0126

Schmidt-Arras D, Rose-John S

IL-6 pathway in the liver: from physiopathology to therapy
J Hepatol. 2016 Jun;64(6):1403-15. doi: 10.1016/j.jhep.2016.02.004. Epub 2016 Feb 8.

Schoknecht T, Schwinge D, Stein S, Weiler-Normann C, Sebode M, Mucha S, Otto B, Ellinghaus E, Stahl F, Franke A, Lohse AW, Herkel J, Schramm C

CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood
J Leukoc Biol. 2016 Sep 14. pii: jlb.5A1015-469R. [Epub ahead of print]

Schwinge D*, von Haxthausen F*, Quaas A, Carambia A, Otto B, Glaser F, Höh B, Thiele N, Schoknecht T, Huber S, Steffens N, Lohse AW, Herkel J, Schramm C

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related with IL-12 signaling
J Hepatol. 2016 Dec 10. pii:S0168-8278(16)30705-X. doi: 10.1016/j.jhep.2016.12.001. [Epub ahead of print]
*equally contributing authors

Seitz S, Iancu C, Volz T, Mier W, Dandri M, Urban S, Bartenschlager R

A Slow Maturation Process Renders Hepatitis B Virus Infectious
Cell Host Microbe. 2016 Jul 13;20(1):25-35. doi: 10.1016/j.chom.2016.05.013. Epub 2016 Jun 16.

Sellau J, Alvarado CF, Hoenow S, Mackroth MS, Kleinschmidt D, Huber S, Jacobs T

IL-22 dampens the T cell response in experimental malaria
Sci Rep. 2016 Jun 17;6:28058. doi: 10.1038/srep28058.

Simerzin A, Zorde-Khvalevsky E, Rivkin M, Adar R, Zucman-Rossi J, Couchy G, Roskams T, Govaere O, Oren M, Giladi H, Galun E

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry
Hepatology. 2016 Jun 15. doi: 10.1002/hep.28679. [Epub ahead of print]

Than NN, Wiegard C, Weiler-Normann C, Füssel K, Mann J, Hodson J, Hirschfield GM, Lohse AW, Adams DH, Schramm C, Oo YH

Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy
Scand J Gastroenterol. 2016 Mar;51(3):329-36. doi: 10.3109/00365521.2015.1095351. Epub 2015 Oct 12

Theeß W, Sellau J, Steeg C, Klinke A, Baldus S, Cramer JP, Jacobs T

Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection
Infect Immun. 2016 Dec 29;85(1). pii: e00475-16. doi:10.1128/IAI.00475-16.

Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst AK

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Oncotarget. 2016 Sep 27;7(39):63730-63746. doi: 10.18632/oncotarget.11650

Wehmeyer MH, Zyriax BC, Jagemann B, Roth E, Windler E, Schulze Zur Wiesch J, Lohse AW, Kluwe J

Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern
Medicine (Baltimore). 2016 Jun;95(23):e3887. doi: 10.1097/MD.0000000000003887.

Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C

Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling
J Biol Chem. 2016 Jul 29;291(31):16186-96. doi: 10.1074/jbc.M116.718551. Epub 2016 May 23.

Wroblewski R, Armaka M, Kondylis V, Pasparakis M, Walczak H, Mittrücker HW, Schramm C, Lohse AW, Kollias G, Ehlken H

Opposing Role of Tumor Necrosis Factor Receptor 1 Signaling in T Cell Mediated Hepatitis and Bacterial Infection In Mice
Hepatology. 2016 Mar 17. doi: 10.1002/hep.28551. [Epub ahead of print]

Zahavi T, Lanton T, Divon MS, Salmon A, Peretz T, Galun E, Axelrod JH, Sonnenblick A

Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation associated liver cancer model
Oncotarget. 2016 Jan 26;7(4):4860-70. doi: 10.18632/oncotarget.6638