2021

Carambia A, Gottwick C, Schwinge D, Stein S, Digigow R, Şeleci M, Mungalpara D, Heine M, Schuran FA, Corban C, Lohse AW, Schramm C, Heeren J, Herkel J.

Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis.
Immunology. 2021 Apr;162(4):452-463

Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, Zeira E, Bahar Halpern K, Caruso S, Zucman-Rossi J, Axelrod JH, Galun E, Goldenberg DS.

The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
Oncogene. 2021 Jan;40(1):127-139

Horst AK, Kumashie KG, Neumann K, Diehl L, Tiegs G.

Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease.
Cell Mol Immunol. 2021 Jan;18(1):92-111

Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, Conradi LC, Haubrock M, Beißbarth T, Leha A, Johnsen SA, Ghadimi BM, Rose-John S, Grade M, Wienands J.

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Cancers (Basel). 2021 Jan 26;13(3):455

Kohsar, M., Landahl, J., Neumann-Haefelin, C., & Schulze Zur Wiesch, J.

Human hepatitis D virus-specific T cell epitopes.
JHEP reports : innovation in hepatology 2021 3(4):100294

Morgan MA, Galla M, Grez M, Fehse B, Schambach A.

Retroviral gene therapy in Germany with a view on previous experience and future perspectives.
Gene Ther. 2021 Mar 22.

Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf AE, Hess LU, Ziegler AE, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs CF, Franke A, Friese MA, Oldhafer KJ, Fischer L, Altfeld M, Lohse AW, Huber S, Tolosa E, Gagliani N, Schramm C.

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis.
J Hepatol. 2021 Mar 24:S0168-8278(21)00219-1

Preti M, Schlott L, Lübbering D, Krzikalla D, Müller AL, Schuran FA, Poch T, Schakat M, Weidemann S, Lohse AW, Weiler-Normann C, Sebode M, Schwinge D, Schramm C, Carambia A, Herkel J.

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver.
JCI Insight. 2021 Mar 22;6(6):141462

Sadeh R, Sharkia I, Fialkoff G, Rahat A, Gutin J, Chappleboim A, Nitzan M, Fox-Fisher I, Neiman D, Meler G, Kamari Z, Yaish D, Peretz T, Hubert A, Cohen JE, Salah A, Temper M, Grinshpun A, Maoz M, Abu-Gazala S, Ben Ya’acov A, Shteyer E, Safadi R, Kaplan T, Shemer R, Planer D, Galun E, Glaser B, Zick A, Dor Y, Friedman N.

ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin.
Nat Biotechnol. 2021 Jan 11

Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF.

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
Sci Immunol. 2021 Feb 23;6(56):eabf6692