New on sfb841-tv: Hepatitis D virus survives longer than previously thought
17 January 2014
The hepatitis D virus (HDV) is not independent: it can only leave the host cell and infect new cells if the hepatitis B virus (HBV) is also present. A co-infection with hepatitis D can deteriorate a chronic hepatitis B, the risk of severe disease courses with advanced cirrhosis is significantly increased. Scientists led by SFB principal investigators Prof. Dr. Maura Dandri and Dr. Marc Lütgehetmann now demonstrated for the first time in human liver cells that the HDV may well survive for weeks alone (Giersch et al., Journal of Hepatology, 2013). Dr. Lütgehetmann explains their research in a recent sfb841-tv video abstract. The findings on the viability of the virus may explain why chronically with hepatitis B and D virus-infected patients often have problems with relapses. New HDV-specific therapeutic approaches are urgently needed.
Giersch K, Helbig M, Volz T, Allweiss L, Mancke LV, Lohse AW, Polywka S, Pollok JM, Petersen J, Taylor J, Dandri M, Lütgehetmann M
Persistent hepatitis Dvirus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection
J Hepatol. 2014 Mar;60(3):538-44. doi: 10.1016/j.jhep.2013.11.010.