B7 - The role of hepatic lipid profiles in liver inflammation, fibrogenesis and carcinogenesis

B7_April 2014

Principal investigator:
Dr. med. Johannes Kluwe
I. Department of Internal Medicine
University Medical Center Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg
Phone: +49-40-7410-51114
Fax: +49-40-7410-52989
E-Mail: j.kluwe@uke.de

Project description
Our proposal focuses on the role of hepatic lipid profiles in NASH-induced inflammation, fibrosis and carcinogenesis. Studies in genetically modified mice address the hypotheses that (1) Myeloperoxidase is required for lipid peroxidation, fibrosis and HCC in NASH, (2) that hepatocellular deletion of lipoprotein lipase will affect NASH-specific lipidome and thus fibrosis and inflammation and (3) that hepatic stellate cells are essential for lipid-mediated inflammation in fatty liver disease. Finally, we are planning to identify lipidomic risk profiles for NASH-progression in patients.

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TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
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