C8 - IL-22 and IL-22BP in liver regeneration and carcinogenesis

C8_April 2014

Principal investigator:
Prof. Dr. med. Samuel Huber
I. Medizinische Klinik und Poliklinik
Universitätsklinikum Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg
Tel.: +49-40-7410-57273
E-mail: shuber@uke.de

Participating stuff

Dr. rer. nat. Tanja Bedke – PostDoc
Sandra Wende – BTA
Mustafa Shiri – PhD student
Morsal Sahibi – PhD student

Project description
Interleukin 22 (IL-22) is a pleiotropic cytokine, which may have protective and pathogenic properties depending on the environment. It particularly plays a role during regeneration, infection, and carcinogenesis. Normally, IL-22 binds to the membrane-bound IL-22 receptor (IL-22r1) thereby exerting its activities. However, there is also a soluble IL-22 receptor, the IL-22 binding protein (IL-22BP), which binds and neutralizes IL-22.

IL-22 seems to play a protective role during liver regeneration. However, uncontrolled IL-22 activity might promote liver cancer.

C08 in 60 SecondsVideoarchiv

C08 in 60 Seconds online seit 29.04.2019

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Sellau J, Alvarado CF, Hoenow S, Mackroth MS, Kleinschmidt D, Huber S, Jacobs T

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Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, König A, Rauch U, Benten D, Izbicki JR, Rösch T, Lohse AW, Strowig T, Gagliani N, Flavell RA, Huber S

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Gagliani N, Hu B, Huber S, Elinav E, Flavell RA

The fire within: microbes inflame tumors
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
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Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17.

Our previous findings have shown that IL-22BP plays a crucial role in controlling the activity of IL-22 during wound healing and carcinogenesis. Now we aim to identify the cellular source of IL-22 and IL-22BP in the liver. Furthermore, we are interested in the pathways regulating IL-22 and IL-22BP production. Finally, we want to investigate the interaction between IL-22 and IL-22BP and how this controls liver regeneration and carcinogenesis.
Our long-term aim is to identify new therapeutic strategies that, on the one hand, promote liver regeneration and, on the other hand, inhibit liver carcinogenesis.