P1 B-cells in autoimmune liver disease

Principal Investigator:
Prof. Dr. med. Mascha Binder
University Medical Center Halle
University Hospital and Polyclinic for Internal Medicine IV
Ernst-Grube-Str. 40
06120 Halle (Saale)

Telefon:(0345) 557 2924
Telefax:(0345) 557 2950
E-Mail: innere4@uk-halle.de

Participating staff:
Dr. rer. nat. Nuray Akyüz – PostDoc
Barbara Gösch – Technical Assistant
Dr. Christoph Schlutheiß – PostDoc

P01 in 60 SecondsVideoarchiv

P01 in 60 Seconds online seit 22.10.2018

Project description

Previous work on the etiology of autoimmune hepatitis (AIH) is almost exclusively concerned with the inflammatory role of CD4 + T lymphocytes. However, the observation that AIH patients have high serum levels of immunoglobulin G (IgG) and circulating autoantibodies also suggests pathological regulation by B lymphocytes.

This assumption is corroborated by the presence of liver infiltrating plasma cells. On the basis of these observations, we want to understand the role of B cells in AIH in more detail, in particular whether there is an AIH-specific cytokine milieu responsible for B cell dysregulation and which molecular target structures of liver-infiltrating B lymphocytes are detected. Especially with regard to the latter question, in close cooperation with project B05, we want to investigate to what extent B lymphocytes lead to liver damage via modulation of T lymphocytes.