P1 B-cells in autoimmune liver disease
Prof. Dr. med. Mascha Binder
University Medical Center Halle
University Hospital and Polyclinic for Internal Medicine IV
06120 Halle (Saale)
Telefon:(0345) 557 2924
Telefax:(0345) 557 2950
Dr. rer. nat. Nuray Akyüz – PostDoc
Barbara Gösch – Technical Assistant
Dr. Christoph Schlutheiß – PostDoc
Previous work on the etiology of autoimmune hepatitis (AIH) is almost exclusively concerned with the inflammatory role of CD4 + T lymphocytes. However, the observation that AIH patients have high serum levels of immunoglobulin G (IgG) and circulating autoantibodies also suggests pathological regulation by B lymphocytes.
This assumption is corroborated by the presence of liver infiltrating plasma cells. On the basis of these observations, we want to understand the role of B cells in AIH in more detail, in particular whether there is an AIH-specific cytokine milieu responsible for B cell dysregulation and which molecular target structures of liver-infiltrating B lymphocytes are detected. Especially with regard to the latter question, in close cooperation with project B05, we want to investigate to what extent B lymphocytes lead to liver damage via modulation of T lymphocytes.