P4 Progression from NAFLD to NASH: Miscommunication between the intestinal microbiota and CD4 T cells as a potential cause

P04_Gagliani_FP3

Principal Investigator:
Prof. Nicoala Gagliani, Ph.D.
I. Medical Center
General, Visceral and Thoracic Surgery Department
University Medical Center Hamburg-Eppendorf
Martinistrasse 52
20246 Hamburg
Tel.: +49-40-7410-52495
Fax: +49-40-7410-59092
E-Mail: n.gagliani@uke.de

Participating staff:

Dr. med. Scognamiglio -PostDoc
Dr. Babette Steglich – PostDoc
Merket – TA

Project Description

The reason why only a fraction of patients suffering from Non Alcoholic Fatty Liver Disease (NAFLD) progress to Non-Alcoholic Steatohepatitis (NASH) is not clear. Studies on mouse models suggest a role of the intestinal microbiota in this progression.

The intestinal microbiota has an active crosstalk with the immune system, in particular with the CD4+ T cells. CD4+ T cells are considered the main orchestrator of the immune response and they exert their function by secreting a variety of cytokines. Based on this, we hypothesise that “bad” intestinal microbiota promotes the capacity of intestine-derived CD4+ T cells to co-produce multiple cytokines: a cellular phenomenon described as plasticity. In the liver, these plastic cells orchestrate a pathogenic immune response driving NASH.

In summary, this project aims to establish a connection among the intestinal microbiota, the immune system and NASH development and in doing so, identify new therapeutic targets for futures therapies.

P04 in 60 SecondsVideoarchiv

P04 in 60 Seconds online seit 14.02.2019